摘要：【摘要】 The tuberous sclerosis-2 ( Tsc-2 ) gene is a suppressor of renal tumorigenesis and an early target of reactive oxygen species-induced renal cancer。 Quinol-thioether-transformed rat r...

摘要：【摘要】 Hyperglycemia-induced alterations in mesangial (MES) cell function and extracellular matrix (ECM) protein accumulation are seen in diabetic glomerulopathy。 Transforming growth factor...

摘要：【摘要】 The effect of arginine vasopressin (AVP) and/or atrial natriuretic peptide (ANP) on the regulation of intracellular pH (pH i ) via H + -ATPase and of cytosolic calcium ([Ca 2+ ] i ) w...

摘要：【摘要】 The renal peptide transporter PEPT2 plays an important role in absorption of di- and tripetides in the proximal tubule。 however, knowledge of regulation of PEPT2 by growth factors an...

摘要：【摘要】 The optimal use of cisplatin as a chemotherapeutic drug has been limited by its nephrotoxicity。 Murine models have been used to study cisplatin-induced acute renal failure。 After ci...

摘要：【摘要】 Heme oxygenase-1 (HO-1) and p21 influence cell fate, and genetic HO-1 overexpression upregulates p21 and confers resistance to apoptosis。 The present study examined the effects of he...

摘要：【摘要】 In macrophages, changes in intracellular calcium have been associated with activation of cellular processes that regulate cell adhesion and motility and are important for the response...

摘要：【摘要】 The secretion and synthesis of renin as the key regulator of the renin-angiotensin-aldosterone system are directly controlled by ANG II in the sense of a negative feedback。 Because w...

摘要：【摘要】 A key task for the multifunctional von Hippel-Lindau protein (pVHL) is regulation of the activity of hypoxia-inducible factor-1 (HIF-1 ) by targeting it to the proteasome for degradat...

摘要：【摘要】 L-type Ca 2+ channels predominantly influence preglomerular arterioles, but there is less information regarding the role of T-type Ca 2+ channels in regulating the renal microvasculat...

摘要：【摘要】 The aim of the present study was to investigate the role of Ca 2+ -activated Cl - channels in the renal vasoconstriction elicited by angiotensin II (ANG II) and norepinephrine (NE)。 ...

摘要：One of the key factors in concentrating the urine is the renal collecting duct osmotic water permeability ( P f ) response to antidiuretic hormone (ADH)。 Neonatal cortical collecting ducts have a ...

摘要：【摘要】 The aim of this study was to determine whether protein kinase C- (PKC- ) is involved in the repair of mitochondrial function and/or active Na + transport after oxidant injury in renal...

摘要：【摘要】 Controversy exists regarding the effect of A 1 adenosine receptor (AR) activation in the kidney during ischemia and reperfusion (I/R) injury。 We sought to further characterize the ro...

摘要：【摘要】 The present study investigated sodium balance and renal tubular function in cirrhotic rats with chronic blockade of the nitric oxide (NO) system。 Three weeks of daily sodium balance ...

摘要：【摘要】 ANG II induces secretion and activation of transforming growth factor- (TGF- ) by glomerular mesangial cells。 Thrombospondin-1 (TSP-1), which is produced by mesangial cells in damage...

摘要：【摘要】 Dietary salt intake modulates the renin-angiotensin system (RAS)。 however, little is known about the effect of salt intake on the progression of glomerulonephritis。 We investigated ...

摘要：【摘要】 Glomerular epithelial cell (GEC) injury and apoptosis may contribute to sclerosis in glomerulonephritis。 The present study addresses signals that regulate survival of GEC in culture ...

摘要：Abnormal Cl - secretion is implicated in cyst enlargement in autosomal dominant PKD (ADPKD), but little is known about transport abnormalities in autosomal recessive PKD (ARPKD)。 We developed a me...

摘要：【摘要】 Inhibition of clathrin-mediated endocytosis by expression of a GTPase-deficient dynamin mutant (dynamin-2/K44A) for 16 h results in an accumulation of plasma membrane aquaporin-2 (AQP...

摘要：【摘要】 Despite its principal mechanical function in the storage and release of urine, the biomechanical properties of the urethra have remained largely unexplored。 The purpose of this study...

摘要：In addition to short-term regulation of aquaporin-2 trafficking, vasopressin also has long-term effects to regulate the abundances of aquaporins-2 and -3 and - and -subunits of the epithelial sodiu...

摘要：The inductive interactions and differentiation events are modulated by a number of transcription factors, protooncogenes, and growth factors and their receptors, which regulate the expression of ta...

摘要：【摘要】 Over the past decade, compelling in vivo and in vitro studies have highlighted lipoxins (LXs) and aspirin-triggered LXs (ATLs) as endogenously produced anti-inflammatory eicosanoids。...