摘要:Progesterone time- and concentration-dependently downregulated extracellular superoxide dismutase (ecSOD) and manganese superoxide dismutase (MnSOD) expression and enzyme activity and reversed 17-e...
07-05-18摘要:Abstract Activation of nuclear factor (NF)-B by angiotensin II (Ang II) plays an essential role in stimulating expression of vascular adhesion molecules, which are essential for vascular inflammati...
07-05-18摘要:Abstract Recent studies suggest that the superoxide generating enzyme NADPH oxidase may play a functional role in regulating cerebral vascular tone。 We tested whether the activity, function, and e...
07-05-18摘要:the Departamento de Farmacologe (J。V。E。) and Unidad Mixta Universidad de ValenciaeCFundacie Centro Nacional de Investigaciones Cardiovasculares Carlos III (C。N。, V。M。V。, R。T。, P。D。), Fa...
07-05-18摘要:Haplotype-specific differences in MMP1 mRNA level in atherosclerotic tissues were also detected。4eC6 Matrix metalloproteinase (MMP)-1 (or interstitial collagenase) can degrade fibrillar collagens,...
07-05-18摘要:Abstract The Drosophila pair-rule gene even skipped (eve) is required for embryonic segmentation and later in specific cell lineages in both the nervous system and the mesoderm。 The homeobox-conta...
07-05-18摘要:Key Words: nitric oxide endothelial cells vascular remodeling transforming growth factor- Introduction Transforming growth factor (TGF)- plays a major role in the vascular response to injury by con...
07-05-18摘要:We recently demonstrated that Am80, a synthetic retinoic acid receptor -specific agonist, inhibits the activity of the transcription factor KLF5, which is essential for neointima formation after va...
07-05-18摘要:The chemokine receptor CXCR4 is essential for migration and homing of hematopoietic stem cells。 Therefore, we investigated the role of CXCR4 and its downstream signaling cascade for the angiogenic...
07-05-18摘要:Abstract The disease mechanism underlying myotonic dystrophy type 1 (DM1) pathogenesis in skeletal muscle may involve sequestration of RNA binding proteins in nuclear foci of expanded poly(CUG) RNA...
07-05-18摘要:18 Phosphorylation and Isoelectric Focusing Myofibrillar proteins were treated with phosphatase and PKA as described。18 Cardiac Function In vivo cardiac function was assessed both by noninvasive e...
07-05-18摘要:Abstract Store-operated calcium (SOC) entry represents the principal Ca2+ entry pathway into nonexcitable cells。 The endothelial ISOC channel is a Ca2+-selective SOC entry channel to which the tra...
07-05-18摘要:Chromatin immunoprecipitation assays reveal that TGF-1 induces Smad3 binding to the SM22 promoter in vivo。 A multimerized SBE promoter responsive to TGF-1 signaling is highly activated by Smad3 bu...
07-05-18摘要:We have previously shown that several disease-linked RyR2 mutations in the C-terminal region enhance the sensitivity of the channel to activation by luminal Ca2+。 Cells expressing these RyR2 mutan...
07-05-18摘要:Abstract 2-Adrenergic receptors (2ARs) are widely expressed, although their physiological relevance in many tissues is not yet fully understood。 Adrenergic mechanisms in blood vessels: morphologic...
07-05-18摘要:Abstract Previously we showed L-4F, a novel apolipoprotein A-I (apoA-I) mimetic, improved vasodilation in 2 dissimilar models of vascular disease: hypercholesterolemic LDL receptoreCnull (LdlreC/eC...
07-05-18摘要:Aggregated IgG, the known ligand for Fc receptors, causes parallel okadaic acideCsensitive loss of eNOS function, FcRIIB expression is demonstrable in endothelium, and heterologous expression studi...
07-05-18摘要:Abstract Bone morphogenetic proteins (BMPs) play important roles in cardiovascular development。 Bone morphogenetic proteins (BMPs) are growth and differentiation factors of the transforming growth...
07-05-18摘要:Results High GlucoseeC and CAE2181-2190eCDependent Degradation of GLUT-1 mRNA Probes The role of CAE2181-2190 in regulating bovine GLUT-1 mRNA stability in vascular cells was studied in an in vitro...
07-05-18摘要:Abstract Increases in Ca2+ influx through the L-type Ca2+ channel (LTCC, Cav1。2) augment sarcoplasmic reticulum (SR) Ca2+ loading and the amplitude of the cytosolic Ca2+ transient to enhance cardi...
07-05-18摘要:Tg Expression of CryABR120G Impairs the Delivery of Ubiquitinated Proteins Into 20S Proteasomes By crossbreeding UPS functional reporter (GFPdgn) mice with CryABR120G Tg mice, we are able to prove ...
07-05-18摘要:Abstract Bone marroweCderived cells (BMCs) have been implicated as a modifiers of vascular growth either directly by transdifferentiation into endothelial cells (ECs) or indirectly through growth f...
07-05-18摘要:Overexpression of PDGF-D Induces Vascular Remodeling The expansion of interstitial connective tissue caused a disorganized capillary network, with areas of lower capillary density than normally fou...
07-05-18