摘要:Rather, we want to shine a light on the reckless comments actor Tom Cruise has recently made that psychiatry is a “quack“ field and his belief that postpartum depression cannot be treated pharmac...
07-05-11摘要:“Blanchard told the JCI that for years, the Whitaker Foundation was the only institution in the country that gave any organized support to the then up-and-coming field of biomedical engineering。 ...
07-05-11摘要:In March, singer Willie Nelson and his wife, Annie, put on a benefit concert to raise funds for a stem cell program at The University of Texas Southwestern Medical Center at Dallas。 The concert ra...
07-05-11摘要:The most common type of stroke, ischemic stroke, affects nearly 700,000 people per year, or 1 person every 45 seconds。 Because stroke is notoriously difficult to treat, a sought-after approach is ...
07-05-11摘要:zaMessage in a bottle: the making of fetal alcohol syndrome, by Janet Golden, is the most comprehensive and easily read text on the history, politics, public health debate, legislation, psychosocia...
07-05-11摘要:eduFew medical histories are as compelling as the story of the conquest of poliomyelitis。 Beginning in 1906, when the virus that causes poliomyelitis — poliovirus — was identified, many scientis...
07-05-11摘要:AbstractThe thyroid-stimulating hormone receptor (TSHR) is a G protein–linked, 7–transmembrane domain (7-TMD) receptor that undergoes complex posttranslational processing unique to this glycoprot...
07-05-11摘要:AbstractIon channels are pore-forming proteins that provide pathways for the controlled movement of ions into or out of cells。 Diseases caused by mutations in genes that encode ion channel subunit...
07-05-11摘要:AbstractA variety of inherited human disorders affecting skeletal muscle contraction, heart rhythm, and nervous system function have been traced to mutations in genes encoding voltage-gated sodium ...
07-05-11摘要:AbstractMuscle channelopathies are caused by mutations in ion channel genes, by antibodies directed against ion channel proteins, or by changes of cell homeostasis leading to aberrant splicing of i...
07-05-11摘要:AbstractSince the first mutations of the neuronal sodium channel SCN1A were identified 5 years ago, more than 150 mutations have been described in patients with epilepsy。 Many are sporadic mutatio...
07-05-11摘要:AbstractLong QT syndrome, a rare genetic disorder associated with life-threatening arrhythmias, has provided a wealth of information about fundamental mechanisms underlying human cardiac electrophy...
07-05-11摘要:AbstractThe QT interval is the electrocardiographic manifestation of ventricular repolarization, is variable under physiologic conditions, and is measurably prolonged by many drugs。 Rarely, howeve...
07-05-11摘要:AbstractHere we review the current knowledge about the mutations of the gene encoding the cardiac ryanodine receptor (RyR2) that cause cardiac arrhythmias。 Similarities between the mutations ident...
07-05-11摘要:AbstractThe transport of anions across cellular membranes is crucial for various functions, including the control of electrical excitability of muscle and nerve, transport of salt and water across ...
07-05-11摘要:AbstractATP-sensitive potassium (KATP) channels, so named because they are inhibited by intracellular ATP, play key physiological roles in many tissues。 cells, these channels regulate glucose-depe...
07-05-11摘要:, through targeted disruption of the Hjv gene (see the related articles beginning on pages 2180 and 2187)。 These mutant mice will allow further investigation into the role of HJV in the regulation...
07-05-11摘要:In mammalian cells, 3 distinct isoforms of Akt exist, but their precise roles in cardiovascular biology were previously unknown。 Three separate studies published in this issue of the JCI now provi...
07-05-11摘要:AbstractReports of neoplasia related to insertional activation of protooncogenes by retroviral vectors have raised serious safety concerns in the field of gene therapy。 Modification of current app...
07-05-11摘要:See the related article beginning on page 2169Spring 。
07-05-11摘要:AbstractThe discovery of the antiinflammatory effect of insulin and the proinflammatory effect of glucose has not only provided novel insight into the mechanisms underlying several disease states b...
07-05-11摘要:The reasons for the different results are not known, but these data suggest that the role of these receptors in atherogenesis remains unresolved。See the related article beginning on page 2192In th...
07-05-11摘要:AbstractThe distinction between peptides that bind to class II MHC products under laboratory conditions and those that do so physiologically is important for the prediction of antigens recognized b...
07-05-11摘要:AbstractBile acids are natural detergents that assist in the absorption and digestion of fats in the intestine。 In liver, the synthesis of bile acids from cholesterol is regulated by multiple sign...
07-05-11摘要:AbstractAlthough increased external load initially induces cardiac hypertrophy with preserved contractility, sustained overload eventually leads to heart failure through poorly understood mechanism...
07-05-11摘要:AbstractG-CSF is a potent hematopoietic factor that enhances survival and drives differentiation of myeloid lineage cells, resulting in the generation of neutrophilic granulocytes。 Here, we show t...
07-05-11摘要:AbstractAkt, or protein kinase B, is a multifunctional serine-threonine protein kinase implicated in a diverse range of cellular functions including cell metabolism, survival, migration, and gene e...
07-05-11摘要:In support of a possible role for hemoglobin (Hb) as a sensor and effector of hypoxic vasodilation, here we show biochemical evidence that Hb exhibits enzymatic behavior as a nitrite reductase, wit...
07-05-11摘要:AbstractHIV infection leads to decreases in the number of CD4+ T lymphocytes and an increased risk for opportunistic infections and neoplasms。 The administration of intermittent cycles of IL-2 to ...
07-05-11摘要:AbstractThe molecular characterization of leukemia has demonstrated that genetic alterations in the leukemic clone frequently fall into 2 classes, those affecting transcription factors (e。, AML1-E...
07-05-11摘要:Dietary iron sensing and inflammation converge in the control of iron absorption and retention by regulating the expression of hepcidin, a regulator of the iron exporter ferroportin。 also known as...
07-05-11摘要:AbstractHereditary hemochromatosis is an iron-overload disorder resulting from mutations in proteins presumed to be involved in the maintenance of iron homeostasis。 Mutations in hemojuvelin (HJV) ...
07-05-11摘要:AbstractPollen exposure induces allergic airway inflammation in sensitized subjects。 The role of antigenic pollen proteins in the induction of allergic airway inflammation is well characterized, b...
07-05-11摘要:Two scavenger receptors, scavenger receptor A (SR-A) and CD36, have been centrally implicated in this lipid uptake process。 This work has contributed to an atherosclerosis paradigm: scavenger rece...
07-05-11摘要:The synthesis and excretion of bile acids were found to be dramatically elevated in these mutants, and the expression of 2 key bile acid synthase genes, cholesterol 7-hydroxylase (Cyp7a1) and stero...
07-05-11摘要:AbstractExpression of voltage-gated K+ channel, shaker-related subfamily, member 5 (KCNA5) underlies the human atrial ultra-rapid delayed rectifier K+ current (IKur)。 The KCNA5 polymorphism result...
07-05-11摘要:AbstractPlasma LDL levels and atherosclerosis both increase on a saturated fat–rich (SAT) diet。 LDL cholesterol delivery to tissue may occur via uptake of the LDL particles or via selective uptak...
07-05-11摘要:AbstractThe fusion peptide (FP) in the N terminus of the HIV envelope glycoprotein, gp41, functions together with other gp41 domains to fuse the virion with the host cell membrane。 We now report t...
07-05-11摘要:Original citation: J。 Clin。 Invest。 115:1030–1038 (2005)。 doi:10。1172/JCI20052396Citation for this erratum: J。 Clin。 Invest。 115:2297 (2005)。 doi:10。1172/JCI20052396E1During the preparat...
07-05-11摘要:Original citation: J。 Clin。 Invest。 115:1030–1038 (2005)。 doi:10。1172/JCI22849Citation for this erratum: J。 Clin。 Invest。 115:2297 (2005)。 doi:10。1172/JCI22849E1The name of 1 of the auth...
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