摘要：16Angiogenic growth factors have been used in tissue repair studies including those related to improving ischemic conditions。Matrigel and Growth FactorsExperimental groups are shown in Table 1 。 ...

摘要：【摘要】 Interleukin-4 (IL-4) has been detected in both human and mouse atherosclerotic lesions, although its effects on the development of the disease are undefined。 J Interferon Cytokine Re...

摘要：In Vivo Validation of the Tet Off-Regulated CD44s Expression SystemTo test whether the in vitro Tet Off-regulated CD44 expression system is also functional in vivo, we developed the Tet Off-regulat...

摘要：To analyze the effects of Nox1 expression and its relation to cellular ROS and signal transduction involved in cellular proliferation, Nox1RNAi constructs were transfected into DU145 prostate cance...

摘要：) deposits, and neurofibrillary lesions, which consist of intracellular aggregates of hyperphosphorylated tau protein。 To study the in vivo induction of tau pathology, dilute brain extracts from a...

摘要：ResultsPUFAs Induce Endogenous S Oligomerization and Aggregation in Primary NeuronsWe first asked whether PUFAs could induce the oligomerization of S at endogenous levels in primary neurons。PUFA-I...

摘要：【摘要】 Inefficient clearance of A。。, caused by impaired blood-brain barrier crossing into the circulation, seems to be a major cause of A。。 accumulation in the brain of late-onset Alzhei...

摘要：--------------------------------------------------------------------------------Oxidative stress is associated with a plethora of pathological conditions, including infection, inflammation, UV and ...

摘要：Deletion of Ilk in both Caenorhabditis elegans and Drosophila melanogaster causes failure of muscle attachment to focal adhesion sites。ResultsGeneration of Conditional Ilk Knockout Mice with Delet...

摘要：【摘要】 Respiratory virus infections can significantly influence the development of airway disease by both predisposing and exacerbating the developing lung immune environment。--------------...

摘要：【摘要】 Gastrointestinal disease and inflammation are common sequelae of human and simian immunodeficiency virus (SIV) infection。Simian immunodeficiency virus (SIV) infection of macaques pre...

摘要：【摘要】 Recent studies have provided evidence that a type I interferon (IFN)-driven immune response might play an important role in the pathogenesis of lichen planus (LP), an inflammatory dis...

摘要：However, regulatory T cells play a crucial role in the overall immune response and are also present within transplanted tissue。 We hypothesize that infiltration of mononuclear cells within kidney ...

摘要：【摘要】 Human immunodeficiency virus (HIV)-1 Tat protein is an important pathogenic factor in HIV-associated neuropathogenesis。 Despite recent progress, the molecular mechanisms underlying T...

摘要：Heme oxygenase (HO) is a rate-limiting enzyme for heme metabolism。 Gene 2004, 336:241-250Ryter SW, Choi AM: Heme oxygenase-1: redox regulation of a stress protein in lung and cell culture models。...

摘要：Macrophage migration inhibitory factor (MIF) is a potent proinflammatory cytokine that may induce TNF- release and play an important role in innate immune and inflammatory responses。--------------...

摘要：Microarray Data AnalysisDetails of the experimental design, hybridization protocols, and raw data sets have been deposited in the Gene Expression Omnibus database (www。 GSE7814) in accordance with...

摘要：【摘要】 Stress alters murine hair growth, depending on substance P-mediated neurogenic inflammation and nerve growth factor (NGF), a key modulator of hair growth termination (catagen inductio...

摘要：Cholangiocytes of the PCK rat may acquire mesenchymal features in response to TGF-。Cell Culture of PCK CholangiocytesBiliary epithelial cells were isolated, purified, and cultured from the intrahe...

摘要：【摘要】 Guanylyl cyclase C (GC-C), the receptor for diarrheagenic enterotoxins and the paracrine ligands guanylin and uroguanylin, regulates intestinal secretion。 Beyond volume homeostasis, ...

摘要：ResultsCharacterization of HH4 Human Hepatocyte LineThe HH4 cell line was created by the introduction of the HPV E6 and E7 genes into hepatocytes isolated from a normal adult liver, followed by der...

摘要：【摘要】 Mucin hypersecretion is a major pathological feature of many respiratory diseases, yet cellular mechanisms regulating secretion of mucin have not been fully elucidated。 Rottlerin als...

摘要：Selective Digestion of Purified 35S-Labeled Proteoglycans35S-labeled proteoglycans were incubated either with chondroitin ABC lyase or a combination of heparinases I, II, and III to remove CS/DS ch...

摘要：Biol Reprod 2003, 68:1755-1763Mueller S, Rosenquist TA, Takai Y, Bronson RA, Wimmer E: Loss of nectin-2 at Sertoli-spermatid junctions leads to male infertility and correlates with severe spermatoz...

摘要：4Monocyte chemoattractant protein-1 (MCP-1) is a potent mononuclear cell chemoattractant produced by a variety of mesenchymal cells, including glomerular cells。Monocytes were isolated from total b...

摘要：32,33 Wound healing in mice lacking the A2AR (A2AR knockout mice) has been shown to be markedly impaired, with decreased and delayed formation of granulation tissue。Isolation of Total RNA from Wou...

摘要：【摘要】 Human serum albumin (HSA) is used as a resuscitation fluid in sepsis。10Human serum albumin (HSA) is a multifunctional plasma protein, with ascribed ligand-binding, transport properti...

摘要：【摘要】 Coxsackievirus B3 (CVB3) is a major cause of acute myocarditis, a serious condition that is refractory to treatment。Evaluation of CVB3-Induced MyocarditisThe severity of CVB3-induced...

摘要：10Myeloperoxidase (MPO) is a 140-kDa heme protein that is predominantly stored in the lysosomes of monocytes and in the azurophilic granules of PMNs。 Myeloperoxidase is reported to directly activa...

摘要：1 in renal proximal tubular epithelial cells by stimulation of initiation phase of mRNA translation。 Although transcriptional mechanisms and altered degradation contribute to changes in protein co...