摘要：From The Heart Research Institute, Sydney, Australia。Correspondence to Philip Barter, The Heart Research Institute, 145 Missenden Road, Camperdown, NSW 2050, Australia。 E-mail p。barter@hri。org。...

摘要：eduIn this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, Rattazzi and colleagues demonstrate definitively that true cartilage and calcified cartilage tissue develop in the artery wal...

摘要：3-containing integrins have been identified: v。3 (also known as the vitronectin receptor) and IIb。3 (also known as platelet glycoprotein [GP] IIb/IIIa)。3 can be expressed by a variety of cell ty...

摘要：Components of the Protein C PathwayThe protein C pathway comprises multiple proteins involved at different points of the pathway, eg, those affecting the protein C activation, those modulating the ...

摘要：41) Role of Platelets in Chronic and Acute InflammationThe goal of inflammation is to rapidly recruit leukocytes to the site of injury or infection。 New York, NY: Oxford University Press。

摘要：One of these peptides is an apolipoprotein A-I (apoA-I) mimetic, D-4F。 apoA-I 。 inflammation IntroductionThe main protein of high-density lipoprotein (HDL), apolipoprotein A-I (apoA-I), contains ...

摘要：Vascular Sources of ROSUnder basal conditions, superoxide anion, a 1-electron reduction product of oxygen, is the primary source from which most other reactive oxidants are derived in the vasculatu...

摘要：Differences in gene expression pattern revealed that many MMPs were upregulated in the thrombus-free wall。 Expression and activity of matrix-degrading proteases were analyzed with gene arrays, qua...

摘要：Peripheral percentages of CD28– T cells of the CD3+CD4+ and the CD3+CD8+ were enriched in AAA patients with 7。 Both CD4+CD28– and CD8+CD28– T cells produced large amounts of IFN- and perforin。...

摘要：From the Laboratoire d’Immunologie Virologie et Bactériologie (R。D。, A。T。, M。G。, R。L。N。), and Laboratoire de Biochimie (R。D。, F。A。, W。H。, P。B。), Reims, France。Correspondence to ...

摘要：edu AbstractObjective— In addition to being a cardiovascular risk marker, recent studies support a role for CRP in atherothrombosis。 Several investigators have reported that CRP binds to Fcgamma ...

摘要：no AbstractObjective— Tetradecylthioacetic acid (TTA) is a hypolipidemic antioxidant with immunomodulating properties involving activation of peroxisome proliferator–activated receptors (PPARs)。...

摘要：jp AbstractObjective— Thymidine phosphorylase (TP) reportedly promotes endothelial cell migration and induces heme oxygenase (HO)-1 expression。 In this study, we examined the effect of TP on VSMC...

摘要：Novel approaches for the prevention of restenosis。 Integrin V。

摘要：Smad7 may represent a novel therapeutic target to reduce the incidence of restenosis。 Smad7 overexpression attenuated the contribution of adventitial cells to neointima formation after vascular in...

摘要：Endothelial marker such as CD31 was expressed in RNA from human umbilical vein endothelial cells and human EPCs, but not expressed in RNA from rat endothelial cells (data not shown)。

摘要：Deparaffinized sections were exposed overnight at 4°C to a 1/25 dilution of a polyclonal antibody to either phosphorylated Y705 or S727 Stat3 (Cell Signaling Technology)。 ResultsI-R Activates Sta...

摘要：At the end of the incubation time, VCAM-1 expression was assessed by cell surface EIA。 At the end of the incubation time, VCAM-1 expression was assessed by cell surface EIA。

摘要：Blood oxygen level–dependent MRI (BOLD MRI) reflects changes in the ratio of oxyhemoglobin to deoxyhemoglobin attributable to their different properties in a magnetic field。 Observed Changes of F...

摘要：nitric oxide IntroductionIdiopathic pulmonary arterial hypertension (IPAH) is a disease of unknown etiology that is characterized by progressive obliteration of small and medium-size pulmonary arte...

摘要：Methods and Results— Gene arrays identified the cytomegalovirus-inducible gene 5 (cig5)/viperin among the genes most potently induced by LPS in human vascular biopsies。 Gene arrays identified the...

摘要：edu AbstractObjective— Advanced atherosclerotic lesions in the innominate arteries of chow-fed apolipoprotein E–deficient mice become highly calcified with 100% frequency by 75 weeks of age。Conc...

摘要：Methods and Results— The combination significantly increased high-density lipoprotein (HDL)–cholesterol levels, apolipoprotein (apo)A-I levels, paraoxonase activity, rendered HDL antiinflammatory...

摘要：de AbstractObjective— To investigate the impact of hepatic ABCA1 on systemic lipoprotein metabolism in vivo by an adenovirus-mediated RNA interference approach。Methods and Results— Efficiency of...

摘要：Conclusions— Statins influence TLR4 expression and signaling via inhibition of protein geranylgeranylation and farnesylation。 Statins induced a dose-dependent downregulation of TLR4 with subseque...

摘要：edu Abstract Objectives— The aim of this study was to determine whether recurrent intravenous injections with Porphyromonas gingivalis (P gingivalis), mimicking periodontitis-associated bacteremia...

摘要：The NADPH oxidase constitutes the main source of superoxide in phagocytic and vascular cells。 This study aimed to investigate the levels of NADPH oxidase–mediated superoxide production in phagocy...

摘要：jp AbstractObjective— Elevated circulating levels of IL-18 can predict future coronary heart disease。 Although IL-18 is thought to play a crucial role in atherosclerosis, whether circulating IL-1...

摘要：20,21 Sensitivity, specificity, and relative risks were calculated for each study outcome using standard formulas。 Ankle-arm index as a marker of atherosclerosis in the Cardiovascular Health Study...

摘要：4 Cystatin C is a 13-kDa protein consisting of 120 amino acids encoded by a 7。Cystatin C concentrations in plasma were measured by immunonephelometry on a Behring Nephelometer II (Dade-Behring, Ma...

摘要：and the Department of Human Genetics (S。 Genetic differences affect susceptibility to disease and whereas premature atherosclerosis can be linked in rare cases to single-gene disorders, most indiv...

摘要：), University of Bristol, Bristol, UK。), London, UK。), University of Bristol, Bristol Royal Infirmary, UK。Correspondence to Dr Martin, University of Bristol, Canynge Hall, Whiteladies Rd, Bristo...

摘要：org AbstractObjective— Levels of tissue factor pathway inhibitor (TFPI) have been associated with arteriosclerosis and thrombotic disease。Levels of TFPI have been associated with both atheroscler...

摘要：8 Monocytes isolated from septic shock patient survivors revealed higher TNF- production than monocytes from nonsurvivors。Quantification of Monocyte TF ActivityTF was measured in the in frozen/tha...

摘要：Thrombin synergistically enhances the collagen-induced platelet procoagulant response。 ResultsThrombin-Induced Intracellular Calcium Response and Platelet Prothrombinase ActivityThrombin is consid...

摘要：A role of Rac1 in the regulation of PAR1 expression was investigated。 Introduction of a Rac1/Cdc42 inhibitory fragment but not a RhoA inhibitory fragment using a cell-penetrating peptide also atte...

摘要：de AbstractObjective— Platelet activation mediates multiple cellular responses, including secretion of chemokines such as RANTES (CCL5), and formation of platelet microparticles (PMPs)。 We studie...

摘要：Platelet leukocyte aggregation and platelet activation were investigated in 58 acute stroke patients。Platelet-Leukocyte Aggregation in Stroke PatientsThe proportion of leukocytes with adherent pla...

摘要：Nonalcoholic fatty liver disease is associated with carotid atherosclerosis: a case-control study。 Clin Liver Dis。 Nonalcoholic fatty liver disease is associated with carotid atherosclerosis: a c...

摘要：Simvastatin accelerated FVa inactivation by 60 seconds (P=0。 Simvastatin did not affect the generation of the 97-kDa fragment of FVa heavy chain (Figure, B)。 Simvastatin depresses blood clotting ...