摘要：From the Sections of Cardiology (V。N。) and Atherosclerosis and Lipoprotein Research (C。M。B。), Department of Medicine, Baylor College of Medicine, and the Center for Cardiovascular Disease Prev...

摘要：Role of ABCA1 in cellular cholesterol efflux and reverse cholesterol transport。 Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class ...

摘要：From the Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia。

摘要：From the Center for Liver, Digestive, and Metabolic Diseases (T。), Laboratory of Pediatrics, University Medical Center Groningen, the Netherlands。 Unité de Recherche 545 (B。), INSERM Départeme...

摘要：Atrial natriuretic peptide increases the intracellular 3‘, 5‘-cyclic guanosine monophosphate (cGMP) concentration which activates cGMP-dependent protein kinase leading to perilipin and hormone-se...

摘要：eduSeries Editor: William HaynesATVB In Focus Noninvasive Assessment of Atherosclerosis: From Structure to FunctionPrevious Brief Reviews in this Series:。 Relationship of Risk Factors and Arterial...

摘要：Plaque Rupture Is the Dominant Cause of Acute Coronary ThrombosisPlaque rupture is the principal cause of luminal thrombosis in acute coronary syndromes occurring in 75% of patients dying of an acu...

摘要：Coculture of Adipocytes and MacrophagesCoculture of adipocytes and macrophages was performed in 2 different ways as follows (Figure I, available online at http://atvb。 ResultsInduction of Inflamma...

摘要：edu AbstractObjective— 12/15-Lipoxygenase (12/15-LO) has been implicated in the pathogenesis of vascular disease。 Vascular smooth muscle cell (VSMC) proliferation is a key component of the respon...

摘要：Stress acutely and chronically increased blood pressure and doubled plasma NPY levels。 Stress- and NPY-induced changes were completely prevented by a selective Y1R antagonist (0。 MethodsBalloon A...

摘要：Vein graft remodeling is incompletely understood。Rabbit Vein Graft Model and In Vivo Gene TransferAll animal experiments were performed in accordance with the requirements outlined by the Guide fo...

摘要：jp AbstractObjective— Rho/Rho-kinase pathway plays pivotal roles in cardiovascular diseases including arteriosclerosis and hypertension。 We examined the involvement of Rho/Rho-kinase signaling in...

摘要：Estrogen treatment reduced carotid artery ligation–induced expression of CRP (protein and mRNA) in the neointima, and lessened CRP-mediated exacerbation of injury。 Neointima formation in the occl...

摘要：From MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK。Correspondence to Maria O’Connell, PhD, MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Rd, Cambrid...

摘要：ca AbstractObjective— Angiotensin (Ang) II-induced vascular damage may be partially mediated by reactive oxygen species generation and inflammation。 We therefore investigated Ang II effects on va...

摘要：edu AbstractObjective— Endothelial cell apoptosis caused by oxidative stress may lead to the loss of microvessels (rarefaction) in hypertension。 Oxidative stress seems to promote endothelial cell...

摘要：Induction of Bradycardia and Stimulation of Collateral GrowthAll surgical procedures and protocols conform to the Guiding Principles for the Care and Use of Animals, were approved by the Council of...

摘要：Delivery of Microbubbles to the Ischemic MuscleArteriogenesis that restores the regional blood flow was observed 3 days after induction of limb ischemia of rats。 Delivery of colloidal particles an...

摘要：uk AbstractObjective— Proteomics and metabolomics are emerging technologies to study molecular mechanisms of diseases。Proteomic and Metabolomic AnalysisFor proteomic and metabolomic analyses, aor...

摘要：type 1 hyperlipoproteinemia IntroductionLipoprotein lipase (LPL) plays a central role in lipoprotein metabolism and energy homeostasis of all vertebrates。 ResultsComplete Rescue of Newborn LPL–/–...

摘要：1,2 Proteases are involved in regulation of cell migration and plaque stability。 DiscussionProtease inhibitors are generally regarded as atheroprotective because proteases participate in matrix de...

摘要：Advanced glycosylation end products (AGEs) (long-term products of the Maillard reaction) have been shown to play a causative role in diabetic vasculopathy and atherosclerosis。 Advanced glycosylati...

摘要：Mice were housed in a pathogen-free animal facility under a standard 12-hour light/12-hour dark cycle。 ResultsCholic Acid Feeding Reduces Cholesterol and ApoA-I Levels in WT and Pxr-Null Mice, but...

摘要：From the VA Palo Alto Health Care System (P。A。, Y。Z。, J。L。), Palo Alto, Calif。 and Institute of Medicinal Biotechnology (J。-D。J。), Chinese Academy of Medical Sciences, Beijing, China。Cor...

摘要：HDL IntroductionCholesteryl ester transfer protein (CETP) is a hydrophobic glycoprotein that plays a central role in human high-density lipoprotein (HDL) metabolism。 Cholesteryl ester transfer pro...

摘要：Department of Veterans Affairs (D。), Veterans Affairs Medical Center, Minneapolis, Minn。edu AbstractObjective— To test the hypothesis whether determination of high-density lipoprotein (HDL) subp...

摘要：edu AbstractObjectives— The purpose of this study was to evaluate the associations between plasma levels of soluble CD40 ligand (sCD40L), atherosclerosis risk factors, and evidence of subclinical ...

摘要：Socioeconomic PositionSEP in childhood or adolescence was assessed in 1980 by parental occupational status (manual。Adult C-Reactive Protein and Carotid IMTWe assessed serum high-sensitive CRP in 2...

摘要：es AbstractObjective— Achilles tendon (AT) xanthomas, specific for familial hypercholesterolemia (FH), may be clinically undetectable。Achilles tendon sonography was performed in 290 subjects with...

摘要：Conclusion— Protein S-S460P has a reduced survival in vivo, which may explain the low levels of free protein S in individuals carrying this polymorphism。 clearance IntroductionProtein S circulate...

摘要：Western Blot for tPACells were lysed with Mammalian Protein Extraction Reagent (Pierce Biotech) and 20 μg of protein per well was loaded and transferred to membranes。

摘要：edu AbstractObjective— The purpose of this study was to investigate the receptor requirements for enhanced IL-1。Methods and Results— ECs were exposed to IL-1。1 μmol/L), but IL-1。1 μmol/L), a...

摘要：Fibrinogen levels were robustly related to the genetic variants (mean increase per allele, 0。15 For example, in a report of a case-control study provocatively titled “Elevated plasma fibrinogen。...

摘要：In the May 2000 issue of Arteriosclerosis, Thrombosis, and Vascular Biology, in the article by Meirhaeghe et al (Arterioscler Thromb Vasc Biol。