摘要：Methods and Results- Cholesterol enrichment of human THP-1 monocytes, alone or in combination with lipopolysaccharide (LPS), tripled their total MV generation, as quantified by flow cytometry based...

摘要：【摘要】 Objective- The present study investigates the role of Src and Syk tyrosine kinases in signaling by G-protein coupled and platelet adhesion receptors。Methods and Results- Using Syk -/...

摘要：Lysophosphatidic acid (LPA) is a small and structurally simple water-soluble phospholipid。 Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-recepto...

摘要：10Platelet activation has a pivotal role in arterial thrombosis。 Platelets were identified with fluorescein isothiocyanate conjugated anti-CD42a (GPIX) monoclonal antibody (MAb) Beb 1 (Becton Dick...

摘要：Conclusion- Antiproliferative agents stimulate the expression of prothrombotic genes。Treatment of Endothelial Cells With Antiproliferative AgentsFor gene array experiments, HCAECs were grown on 15...

摘要：31) and increased mean carotid artery intimal-medial thickness associated with the C promoter polymorphism of Leukotriene C 4 Synthase ( LTC 4 S ) in women。An age-adjusted increased risk for coron...

摘要：In Vivo IVUS-VH AnalysisIVUS was performed in vivo in all the lesions at baseline, 2 weeks, and at euthanization。Characterization of Plaque Components by VHA histology-IVUS-VH correlation analysis...

摘要：【摘要】 Objective- Angiotensin II (AngII) infusion into hypercholesterolemic mice accelerates atherosclerosis and promotes formation of abdominal aortic aneurysms (AAAs)。Methods and Results-...

摘要：Methods and Results- We provide two independent lines of investigation to dissect the effects of Ccr1 and Ccr5 deletion in apolipoprotein E-deficient (ApoE -/- ) mice in a collaboration between Aac...

摘要：【关键词】 angptl high density lipoprotein endothelial lipase phospholipase triglyceride IntroductionPlasma concentrations of high-density lipoprotein (HDL) cholesterol are inversely correlated ...

摘要：Lipoproteins are the major source of such combustible substrate, thereby suggesting the interplay between PPAR activity and lipoprotein modification。 Triglyceride response after high fat challenge...

摘要：【摘要】 Objective- Serum amyloid P (SAP), a pentraxin like C-reactive protein (CRP), functions in innate immunity。 However, associations of SAP with cardiovascular disease (CVD) are unknown。...

摘要：【关键词】 atherosclerosis wall shear stress computational fluid dynamics micro CT twophoton microscopy adhesion molecules IntroductionHemodynamic wall shear stress (WSS) is important in the pat...

摘要：Modulation of TNF-induced protein expression of VCAM-1 and E-Selectin by NO。 Apolipoprotein E and atherosclerosis。 Apolipoprotein E alleles, dyslipidemia, and coronary heart disease。 Apolipoprot...

摘要：Inhibition of VEGFR2 Also Inhibits the Effect of Ox-PAPC on Tissue Factor Synthesis and the Phosphorylation of Erk 1/2We also examined the role of VEGFR2 in another signal transduction pathway acti...

摘要：【摘要】 Objective- Endothelin-1 (ET-1) contributes to the increased peripheral resistance in heart failure and hypertension。 Endothelin-1 is responsible for the increased leg vascular tone i...

摘要：【摘要】 Objective- Blood flow is altered in metabolic and ischemic diseases with dramatic consequences。 Resistance arteries structure and function remodel in response to chronic blood flow c...

摘要：1 Tissue factor pathway inhibitor-2 (TFPI-2) is a Kunitz-type serine proteinase inhibitor 2 synthesized by endothelial cells (ECs), smooth muscle cells (SMCs), and syncytiotrophoblasts, 3,4 which a...

摘要：Effect of L-NNA, 7-NI, NS398, UA, FeTPPS, or TPPS on the Cerebrovascular Actions of AngIICerebrovascular responses to whisker stimulation, Ach, and adenosine were tested while the window was superf...

摘要：【摘要】 Objective- Angiotensin peptides play a central role in cardiovascular physiology and pathology。 Des[Asp 1 ]-[Ala 1 ]-Ang II, in the following named Angiotensin A (Ang A), is most lik...

摘要：【摘要】 Background- Prostacyclin (PGI 2 ) and thromboxane (TxA 2 ) effect disparate outcomes for atherogenesis and the response to vascular injury。 Dimerization of their G protein-coupled re...

摘要：【摘要】 Objective- Since the macrophage colony-stimulating factor (M-CSF) has been shown to stimulate differentiation and proliferation of monocyte/macrophage lineage and to be involved in th...

摘要：【摘要】 Objective- Sphingosine-1-phosphate (S1P) is a bioactive lipid, which influences migration and proliferation of endothelial cells through activation of S1P receptors and has been shown...

摘要：Lipid peroxidation and endothelial cell injury: Implications in atherosclerosis。