摘要：Determination of Second-Order Rate Constant The second-order rate constant (KMTSEA) for the reaction of MTSEA with wild-type CB2 or each mutant was estimated according to the method used by Javitch...

摘要：UCT/MRC Research Group for Receptor Biology, Institute of Infectious Disease and Molecular Medicine, Department of Medicine and Division of Medical Biochemistry, University of Cape Town Faculty of ...

摘要：Choi DW (1988) Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage。 Chuang RS, Jaffe H, Cribbs L, Perez-Reyes E, and Swartz KJ (1998) Inhibition of T...

摘要：Receptor-mediated ligand endocytosis has been used clinically to catalyze the accumulation of stable, radiolabeled somatostatin analogs in tumor cells that express the sst2 receptor (Hofland and La...

摘要：Akt is a protein kinase effector immediately downstream of PI3K。 Both overexpression of a dominant-negative mutant of Akt (K179R) and the addition of 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydr...

摘要：Synergistic cytotoxicity was demonstrated, and pemetrexed significantly decreased the amount of phosphorylated Akt, enhanced apoptosis, and increased the expression of dCK in A549 and Calu-6 cells,...

摘要：) Abstract 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO) and the corresponding methyl (CDDO-Me) and imidazole (CDDO-Im) esters induce peroxisome proliferator-activated receptor (PPAR)-depende...

摘要：To determine whether free G subunits were released from G protein heterotrimers upon peptide treatment, cells were transfected with Ric-8A, a guanine nucleotide exchange factor for free GGDP, but n...

摘要：Appropriate Spacing to the Plasma Membrane Is Required for ER-Retention/Retrieval of GABAB1。

摘要：The CPI-17 (PKC-potentiated inhibitory protein for heterotrimeric myosin light chain phosphatase of 17 kDa) is activated by protein kinase C and acts on a myosin light-chain phosphatase-specific ta...

摘要：), Division of Molecular Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California Abstract GABAA receptor-associated protein (GABARAP) was isolated p...

摘要：To elucidate the role of Mrp3 in these processes, the Mrp3 gene (Abcc3) was disrupted by homologous recombination。 Mrp3eC/eC mice did not exhibit enhanced lethality to etoposide phosphate, althoug...

摘要：Liu P, Liu J, Huang W, Li MD, and Dopico AM (2003) Distinct regions of the slo subunit determine differential BKCa channel responses to ethanol。

摘要：Cernuda-Morollon E, Pineda-Molina E, Canada FJ, and Perez-Sala D (2001) 15-Deoxy-12,14-prostaglandin J2 inhibition of NF-B-DNA binding through covalent modification of the p50 subunit。 Relic B, Be...

摘要：The polysialyltransferases [ST8SiaIV (PST1) and ST8SiaII] are responsible for the addition of polysialic acid (PSA) to NCAM。 Valproic acid (2-n-propylpentanoic acid。 Two enzymes are responsible f...

摘要：Constitutive Signaling by TRH-R1 Mutants Modified in the Cys-335/Lys-338 Domain。

摘要：Membrane exo/endocytic processes, diffusion of macromolecules, and protein activities, among other cellular events, depend on the physical properties of membrane lipids。 Phospholipids were from Av...

摘要：) Abstract Organic anion transporting polypeptides (Oatp) mediate the transport of a wide variety of amphipathic organic substrates。 Hormonal induction of Oatp/OATP expression may provide an impor...

摘要：Physiological Erection Studies。 Results Long-Term Sildenafil Treatment Increases Post-stimulation Erectile Response (Delays Detumescence) in Aged Rats。 Penes from Aged Rats Have Decreased eNOS (S...

摘要：) Abstract Mutations in the KCNH2 or human ether-a-go-goeCrelated gene-encoded K+ channel reduce functional KCNH2 current (IKCNH2) to cause long QT syndrome (LQT2) by multiple mechanisms, including...

摘要：Suramin/DIDS-induced Ca2+ release was only detected in cells that displayed the CICR mechanism, and cell types that do not express this type of CICR mechanism did not exhibit suramin/DIDS-induced C...

摘要：Department of Pharmacology and Toxicology, College of Pharmacy, the University of Arizona, Tucson, Arizona Abstract The EP2 and EP4 prostanoid receptors are G-protein-coupled receptors whose activa...

摘要：1 M imidazole into 15 ml of scintillation fluid (Highsafe III。 Constitutive SRE, NFAT, and NF-B cis-Reporting and CREB trans-Reporting Luciferase Assay。 Results ORF74-EHV2 Displays High Constitut...

摘要：Modeling, Ligand Docking Simulations, and Molecular Dynamics Simulations。 Kroeze WK, Kristiansen K, and Roth BL (2002) Molecular biology of serotonin receptors structure and function at the molecu...

摘要：The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (M。 Flewellen EH, Nelson TE, Jones WP, Arens...

摘要：) Abstract trans-Resveratrol (RV), a polyphenolic stilbene derivative found in grape skin and other food products, has been proposed to exert beneficial effects in cardiovascular disease。 Our grou...

摘要：) Abstract The highly conserved Asn136 is in close proximity to the nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI)-specific lipophilic pocket of human immunodeficiency virus type 1 (HIV...

摘要：Because inhaled anesthetics robustly enhance GABA A receptor (GABAA-R) responses to GABA, these receptors are considered prime targets of anesthetic action。 However, the importance of GABAA-Rs and...