摘要：【关键词】 Phosducin Phosducin (PDC) has been shown in structural and biochemical experiments to bind the G subunit of heterotrimeric G-proteins。 Phosducin (PDC) is a 28-kDa soluble protein ex...

摘要：【关键词】 Aryl Hydrocarbon Receptor The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor with important roles in metabolic adaptation, dioxin toxicology, and vascular...

摘要：【关键词】 Receptor Regulation Axon guidance molecules, critical for neurodevelopment, are also implicated in morphological and other neurodaptative changes mediated by physiological or pharmac...

摘要：Cell surface fluorescence resonance energy transfer studies of cells coexpressing D103A and D1 revealed no signal before agonist treatment but a robust signal after agonist treatment, indicating th...

摘要：【关键词】 Identification We have demonstrated previously that certain members of a series of novel pyrrolo-1,5-benzoxazepine (PBOX) compounds potently induce apoptosis in a variety of human ch...

摘要：【关键词】 Potentiation Divalent cations promote activation of several nicotinic acetylcholine receptor (AChR) subtypes, presumably by lowering the energetic barrier between open and closed con...

摘要：Angiogenesis, the process of new blood vessel formation, is crucial for the development and progression of pathogenic processes of a variety of disorders, including tumor growth (Folkman, 1995)。 C...

摘要：【关键词】 Correction Wang J, Fillebeen C, Chen G, Andriopoulos B, and Pantopoulos K (2006) Sodium nitroprusside promotes IRP2 degradation via an increase in intracellular iron and in the absen...

摘要：Preparation of Boronic Chalcone Derivatives。

摘要：【关键词】 Sphingosine Sphingosine-1-phosphate (S1P) and cannabinoid receptors are G-protein-coupled receptors that mediate the effects of S1P and endocannabinoids, respectively。 Cannabinoid r...

摘要：【关键词】 Peroxisome Proliferator Peroxisome proliferator-activated receptor (PPAR)- and retinoic acid X receptor (RXR) heterodimer regulates cell growth and differentiation。 9-cis-Retinoic a...

摘要：【关键词】 Potent Modulation Voltage-gated sodium channels are essential for the propagation of action potentials in nociceptive neurons。 In our effort to identify isoform-specific and high-af...

摘要：【关键词】 Neuroprotective Neuroprotective effects of estrogens have been shown in various in vitro and in vivo models, but the mechanisms underlying protection by estrogen are not clear。 Effe...

摘要：【关键词】 Reducing We have previously reported that the reducing agent dithiothreitol (DTT) strongly increases thermally induced activity of the transient receptor potential vanilloid receptor...

摘要：【关键词】 Experimental The function of ATP-activated P2X3 receptors involved in pain sensation is modulated by desensitization, a phenomenon poorly understood。 Desensitization properties were...

摘要：【关键词】 Transfection In the context of drug hypersensitivity, our group has recently proposed a new model based on the structural features of drugs (pharmacological interaction with immune r...

摘要：【关键词】 Inhibition DNA topoisomerase I (Top1) is the target of camptothecin, and novel Top1 inhibitors are in development as anticancer agents。 Top1 inhibitors damage DNA by trapping covale...

摘要：Modification of the Monocarbonato Complex (4) by Jurkat Cells。 Uptake of Platinum by Jurkat Cells。 Uptake of Platinum by Cells。 【参考文献】 Acharya AN, Das AC, and Dash AC (2004) Carbo...

摘要：【关键词】 Subtype Specificity Voltage-gated sodium (Nav) channels are modulated by a variety of specific neurotoxins。 Scorpion -toxins affect the voltage-dependence of channel gating: In thei...

摘要：【关键词】 Ketoconazole The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) play a major part in the control of drug metabolism and transport。 Miconazole behaved like ...

摘要：Western Blot of P2X2 Receptor Protein。 P2X2 mRNA Level Is Increased by Retinoids Treatment in PC-12 Cells。 Increase in the level of P2X2 receptor mRNA by 9-cis-retinoic acid。 The Protein Level o...

摘要：Nucleoside Uptake Assays in Cultured Cells。 Nucleoside uptake assays were conducted at room temperature in transport buffer [20 mM Tris-HCl, 3 mM K2HPO4, 1 mM MgCl2(6H2O), 2 mM CaCl2, 5 mM glucose...

摘要：【关键词】 Phospholipase Phospholipase D-mediated hydrolysis of phosphatidylcholine is stimulated by protein kinase C and the monomeric G proteins Arf, RhoA, Cdc42, and Rac1, resulting in compl...

摘要：【关键词】 locus ceruleus We have developed a model system of locus ceruleus (LC) neurons in culture, in which brain-derived neurotrophic factor (BDNF) induces the emergence of noradrenergic ne...

摘要：【关键词】 Specific Rescue Most mutants of the cystic fibrosis transmembrane conductance regulator (CFTR) that cause severe symptoms of cystic fibrosis do not reach the cell surface because the...

摘要：【关键词】 Functional Validation The ATP-binding cassette (ABC) transporter ABCG2 has been implicated to play a significant role in the response of patients to medication and/or the risk of dis...

摘要：【关键词】 Chemical Inducers The regulation of human GSTA1 by chemical inducers of rodent glutathione S-transferases (GSTs) and the regulatory role of hepatic nuclear factor (HNF) 1 was investi...

摘要：【关键词】 Promoter Region The MDR1 multidrug transporter represents one of the better characterized drug transporters that play an important role in protecting the body against xenobiotic insu...

摘要：【关键词】 4-Chloro-m-cresol 4-Chloro-m-cresol (4-CmC) is a clinically relevant activator of the intracellular Ca2+ release channel, the ryanodine receptor isoform 1 (RyR1)。 Structural Diversi...

摘要：【关键词】 Soluble Mimics Signal transduction by G protein-coupled receptors (GPCRs) is mediated by interactions between intracellular proteins and exposed motifs on the cytoplasmic face of the...

摘要：【关键词】 Monocytes Although the level of serum amyloid A has been reported to be up-regulated during inflammatory response, the role of serum amyloid A on the regulation of inflammation and i...

摘要：【关键词】 Untranslated 42 nicotinic acetylcholine receptors (nAChRs) are recognized as the principal nicotine binding site in brain。 Expression of nAChR in Xenopus laevis Oocytes。 Expression...

摘要：【关键词】 High Accumulation Ototoxicity is a typical dose-limiting side effect of cancer chemotherapy with cisplatin but much less so with carboplatin。 To elucidate the underlying molecular p...

摘要：Human gene 2 relaxin is the cognate ligand for relaxin family peptide receptor (RXFP) 1, whereas INSL3 is the ligand for RXFP2。 Constitutively active mutants of both receptors when expressed in hu...

摘要：【关键词】 Possible The class B family of G protein-coupled receptors contains several potentially important drug targets, yet our understanding of the molecular basis of ligand binding and rec...

摘要：【关键词】 Analysis The specificity of G protein signaling demonstrated by in vivo knockouts is greater than expected based on in vitro assays of function。 Production of Fluorescent Fusion Pro...

摘要：Members of our laboratory recently identified the ZIP8 transporter protein, encoded by the mouse Slc39a8 gene, to be responsible for genetic differences in response to cadmium damage of the testis。...

摘要：【关键词】 Allosteric In general, the M2 subtype of muscarinic acetylcholine receptors has the highest sensitivity for allosteric modulators and the M5 subtype the lowest。 Allosteric effects o...

摘要：【关键词】 Hydrocarbon In hepatocyte-derived cell lines, either loss of aryl hydrocarbon receptor (AhR) function or treatment with a persistent AhR agonist such as 2,3,7,8-tetrachlorodibenzo-p-...

摘要：Divalent-evoked currents were blocked by the 7 antagonist methyllycaconitine and were abolished when Glu172 was mutated to glutamine。 K144C/T198C 7 AChRs Are Activated by Both ACh and Divalent Cat...