反相高效液相色谱法拆分α-氯代丙酰替苯胺光学异构体

摘　要：采用反相高效液相色谱法在手性柱上分离芳氧基丙酸类除草剂中间体α-氯代丙酰替苯胺的光学异构体。实验结果表明，在三苯甲酸纤维素酯(CTB)手性柱上，以无水乙醇为流动相时，能在较大程度上拆分α-氯代丙酰替苯胺的光学异构体，其分离因子为1.52，分离度Rh为0.60。

关键词：α-氯代丙酰替苯胺，光学异构体，高效液相色谱，手性固定相
分类号：065　文献标识码：A

Chiral Resolution of Optical Isomers of α-Chloro-N-phenyl propanamide by Reversed Phase HighPerformance Liquid Chromatography

Shi Jiehua（College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032）　
Xu Xiuzhu（Center of Analysis and Measurement, Zhejiang University, Hangzhou 310027）　
Yang Gensheng（College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032）　

Abstract：The chiral resolution of the optical isomers of aryloxypropionic acid herbicide intermediate α-chloro-N-phenyl propanamide was studied by reversed phase high performance liquid chromatography on chiral column. The experimental results showed that the optical isomers of α-chloro-N-phenyl propanamide could be resolved much better on the tribenzoylcellulose (CTB) chiral column with ethanol as mobile phase. The separation factor and separation degree were 1.52 and 0.60 respectively
Keywords：α-Chloro-N-phenyl propanamide, optical isomer, high performance liquid chromatography, chiral stationary phase

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收稿日期：2000年5月22日

修稿日期：2000年11月20日

出版日期：2001年4月1日