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摘 要:采用反相高效液相色谱法在手性柱上分离芳氧基丙酸类除草剂中间体α-氯代丙酰替苯胺的光学异构体。实验结果表明,在三苯甲酸纤维素酯(CTB)手性柱上,以无水乙醇为流动相时,能在较大程度上拆分α-氯代丙酰替苯胺的光学异构体,其分离因子为1.52,分离度Rh为0.60。
Chiral Resolution of Optical Isomers of α-Chloro-N-phenyl propanamide by Reversed Phase HighPerformance Liquid Chromatography Shi Jiehua(College
of Chemical Engineering, Zhejiang University of Technology, Hangzhou
310032) Abstract:The
chiral resolution of the optical isomers of aryloxypropionic acid
herbicide intermediate α-chloro-N-phenyl propanamide was studied by
reversed phase high performance liquid chromatography on chiral column.
The experimental results showed that the optical isomers of α-chloro-N-phenyl
propanamide could be resolved much better on the tribenzoylcellulose (CTB)
chiral column with ethanol as mobile phase. The separation factor and
separation degree were 1.52 and 0.60 respectively |
作者单位:施介华(浙江工业大学化学工程学院,杭州
310032) 徐秀珠(浙江大学分析测试中心,杭州 310027) 杨根生(浙江工业大学化学工程学院,杭州 310032) 参考文献: [1]Toshim T, Masami O,
Keiichi I, Yoshio T. Zasso Kenkyu, 1991,36(1):50~57 收稿日期:2000年5月22日 修稿日期:2000年11月20日 出版日期:2001年4月1日 |
http://www.periodicals.com.cn/qikan/periodical/fxhx/fxhx2001/0104/0104ml.htm