摘要：Interestingly, it was located in a signal transducer and activator of transcription 5B (STAT5B) binding consensus site。 In vitro, we showed that the -681G allele completely abolished the binding o...

摘要：AbstractTopAbstractIntroductionMethodsResultsDiscussionReferencesObjective— MRI is being used to characterize the composition of atherosclerotic plaques。 We studied the utility of a new intravasc...

摘要：AbstractTopAbstractIntroductionMethodsResultsDiscussionReferencesObjective— We conducted a whole-genome, multipoint linkage screen to localize a previously reported major locus accounting for 56% ...

摘要：AbstractTopAbstractIntroductionMethodsResultsDiscussionReferencesObjective— The objective of this study was to investigate ACE- and chymase-dependent angiotensin I-to-II conversion in human corona...

摘要：The stimulatory role of ADP in platelet aggregation has received much attention in recent years。1 Not only is ADP a major physiological agonist on its own, it also plays a key role in promoting ag...

摘要：Rosiglitazone treatment, but not placebo, significantly reduced MMP-9 levels already after 2 weeks by -19。 Rosiglitazone Treatment Reduces MMP-9 Serum Levels in Type 2 Diabetic Patients With CADTo...

摘要：MethodsTopAbstractIntroductionMethodsResultsDiscussionReferencesSubjectsBetween August 1994 and April 1999, 1238 subjects underwent general health screening tests at the Center for Multiphasic Heal...

摘要：Key Words: bicuspid aortic valve aorta dilatation epidemiology population-based study IntroductionTopAbstractIntroductionMethodsResultsDiscussionReferencesBicuspid aortic valve (BAV) disease is th...

摘要：We assessed the influence of a selective P2Y12-receptor antagonist (AR-C69931MX), in conjunction with thrombolytic therapy, on the prevention of platelet aggregation and thrombus formation。5 mg/kg...

摘要：ConclusionsReferencesCholesteryl ester transfer protein (CETP) promotes the transfer of cholesteryl esters from antiatherogenic HDLs to proatherogenic apolipoprotein B (apoB)–containing lipoprotei...

摘要：Methods and Results— MCP-1 mRNA expression was quantitated by Northern blot analysis, and its protein expression was quantitated by immunostaining and ELISA at the age of 1, 3, 6, and 12 months (n...

摘要：AbstractTopAbstractIntroductionMethodsResultsDiscussionReferencesObjective— The transmembrane ligand ephrin-B2 and its receptor tyrosine kinase EphB4 are specifically expressed on arterial and ven...

摘要：Carotid artery intima-media thickness (IMT) is an intermediate phenotype for atherosclerosis。6 Carotid IMT measurements are increasingly being used as an intermediate phenotype for genetic studies...

摘要：Endothelial dysfunction is a systemic disorder and a key variable in the pathogenesis of atherosclerosis and its complications。 Current evidence suggests that endothelial status is not determined ...

摘要：Expansive remodeling, indicated by IEL lengthening exceeding that of normal growth in wild-type C57BL/6 mice, was evident at 6 months of age and showed overcompensation (luminal enlargement) by 13 ...

摘要：Analysis of PON1 ActivityOne hundred fifty cases and the same number of controls were randomly selected from the subjects for PON1 activity measurement。 Statistical AnalysisThe data were analyzed ...

摘要：Randomized Controlled TrialsPossible MechanismsIntake of Omega-3 Fatty。Safety of Omega-3 Fatty。Safety of FishSummaryReferences Since the first AHA Science Advis...

摘要：AbstractTopAbstractIntroductionMethodsResultsDiscussionReferencesObjective— The objective of this study was to investigate the effects of fluvastatin on atherosclerosis, systemic and regional hemo...

摘要：AbstractTopAbstractIntroductionMethodsResultsDiscussionReferencesObjective— The hematopoietically expressed homeobox (HEX) is transiently expressed in endothelial cells (ECs) during vascular forma...

摘要：AbstractTopAbstractIntroductionMethodsResultsDiscussionReferencesObjective— Endothelial nitric oxide synthase (eNOS) activity is supported by tetrahydrobiopterin (BH4), which appears to be importa...

摘要：The small GTPase RhoA previously has been implicated in vascular endothelial growth factor (VEGF)-induced signaling pathways, but its role has not been clarified。 Methods and Results— VEGF induce...

摘要：7 cells heparan-sulfate proteoglycans IntroductionTopAbstractIntroductionMethodsResultsDiscussionReferencesMacrophages in the arterial wall play a crucial role in the progression of atherosclerosi...

摘要：AbstractTopAbstractntroductionMethodsResultsDiscussionReferencesObjective— Tissue factor (TF), the initiator of the coagulation cascade, is expressed by cells in atherosclerotic lesions。 Lysophos...

摘要：AbstractTopAbstractIntroductionMethodsResultsDiscussionReferencesObjective— Transgenic mice expressing human group IIA secretory phospholipase A2 (group IIA sPLA2) spontaneously develop atheroscle...

摘要：AbstractTopAbstractIntroductionMethodsResultsDiscussionReferencesObjective— Chymase released from activated mast cells has been shown to induce apoptosis of vascular smooth muscle cells (SMCs) in ...

摘要：MethodsTopAbstractIntroductionMethodsResultsDiscussionReferencesCell CulturesHuman saphenous and bovine aortic endothelial cells (BAECs) were harvested with type IA collagenase。 Cell Immunofluores...

摘要：Omega-3 fatty acids are obtained from two dietary sources: seafood and certain nut and plant oils。 These are outlined in a recent Scientific Statement, “Fish Consumption, Fish Oil, Omega-3 Fatty ...

摘要：AbstractTopAbstractIntroductionMethodsResultsDiscussionReferencesObjective— Phosphatidylcholine hydroxyalkenals (PC-HAs) are a class of oxidized PCs derived from lipid peroxidation of arachidonate...

摘要：Ischemic stroke is a leading cause of death and disability worldwide and is a major contributor to rising healthcare costs。 It has been estimated that in the United States, an individual is afflic...

摘要：In this study, we investigated the role of mitogen-activated protein kinases (MAPKs) on VSMC proliferation and neointimal formation in the context of aging。 This was associated with a significant ...

摘要：Fenofibrate lowered plasma TG (P0。 Fenofibrate lowered 24-hour (P0。

摘要：LDLs include particle subclasses that have different mobilities on polyacrylamide gradient gels: LDL-I (27。5 nm), LDL-IIa (26。2 nm), LDL-IIb (25。5 nm), LDL-IIIa (24。

摘要：Key Words: familial hypercholesterolemia preventive medicine family screening mutational analysis screening enrichment IntroductionTopAbstractIntroductionMethodsResultsDiscussionReferencesFamilial...

摘要：Treatment with simvastatin (20 mg/kg) after MCAO prevented the increase in brain infarct volume occurring at 24 hours and induced a 46。 Conclusions— Statins, in addition to their preventive effec...

摘要：20,21 In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, Capell and colleagues22 describe the effect of fenofibrate-induced reductions in triglycerides on vascular function。 Func...