反相薄层色谱法测定1-1,2,4-三唑类杀菌剂的疏水性

分类号：O658　文献标识码：A
文章编号：0251-0790（2001）05-0788-03

Lipophilicity Determination of Some 1-1, 2, 4-Triazole Compounds by Reversed-phase Thin Layer Chromatography

JIANG Zheng-Jin（State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China）　
ZHANG Zhi-Chao（State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China）　
YIN Biao-Lin（State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China）　
ZHAO Guo-Feng（State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China）　
WANG Qin-Sun（State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China）　

Abstract：A study has been carried out of evaluating lipophilicity of some 1-1, 2, 4-triazole compounds by RP-HPTLC. An equation that reasonably correlates partition coefficients(clgP) with RM0 values for 23 1-1,2,4-triazole compounds was derived and its predictive capability was tested with five 1-1,2,4-triazole compounds. It has been found that RP-HPTLC can be extensively applied to determining lipophilicity of 1-1,2,4-triazole compounds.

Keywords：RP-HPTLC; 1-1,2,4-Triazole compounds; Quantitative relationship between structure and retention value; Hydrophobic parameter