The DANAMI-2 Trial
Danish Trial in Acute Myocardial Infarction-2
Presented at the American College of Cardiology
51st Annual Scientific Session
Atlanta, GA
Dr. Henning Rud Andersen
for the DANAMI-2 investigators
High-risk ST elevation MI patients (>4 mm elevation), Sx < 12 hrs
5 PCI centers (n=443) and 22 referring hospitals (n=1,129), transfer in < 3 hrs
Lytic therapy
Front-loaded tPA 100 mg
(n=782)
Death / MI / Stroke at 30 Days
DANAMI-2: Study Design
Primary PCI
with transfer
(n=567)
Primary PCI
without transfer
(n=223)
Stopped early by safety and efficacy committee
DANAMI-2: Centers
Death / MI / Stroke (%)
Lytic
Primary PCI
P=0.0003
P=0.002
Combined
Transfer Sites
P=0.048
Non-Transfer Sites
DANAMI-2: Primary Results
RRR 45%
Lytic
Primary PCI
Lytic
Primary PCI
RRR 40%
RRR 45%
Lytic
Primary PCI
P=0.35
Death
DANAMI-2: Results
Lytic
Primary PCI
P=0.15
Stroke
Lytic
Primary PCI
P<0.0001
Recurrent MI