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在线期刊
实验医学杂志
2003年第197卷第1期
CD28 Costimulation Is Required for In Vivo Induction of Peripheral Tolerance in CD8 T Cells
CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms
Critical Role of the Carboxyl Terminus of Proline-rich Tyrosine Kinase (Pyk2) in the Activation of Human Neutrophils by Tumor Necrosis FactorSeparation of Sig
Enhanced B Cell Expansion, Survival, and Humoral Responses by Targeting Death Receptor 6
Flexibility of Mouse Classical and Plasmacytoid-derived Dendritic Cells in Directing T Helper Type 1 and 2 Cell DevelopmentDependency on Antigen Dose and Diff
Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function
Natural Killer Cell Inhibitory Receptors Block Actin Cytoskeleton-dependent Recruitment of 2B4 (CD244) to Lipid Rafts
Negative Regulation of T Cell Receptor–Lipid Raft Interaction by Cytotoxic T Lymphocyte–associated Antigen 4
A Crucial Role of Glycoprotein VI for Platelet Recruitment to the Injured Arterial Wall In Vivo
Positive Selection of Anti–Thy-1 Autoreactive B-1 Cells and Natural Serum Autoantibody Production Independent from Bone Marrow B Cell Development
Secondary Heavy Chain RearrangementA Mechanism for Generating Anti–double-stranded DNA B Cells
2003年第197卷第2期
A Single Amino Acid Alteration in Cytoplasmic Domain Determines IL-2 Promoter Activation by Ligation of CD28 but Not Inducible Costimulator (ICOS)
Differential Regulation of Cathepsin S and Cathepsin L in Interferon –treated Macrophages
DNA Methylation Maintains Allele-specific KIR Gene Expression in Human Natural Killer Cells
Expression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10
Human T Cell Receptor Cells Recognize Endogenous Mevalonate Metabolites in Tumor Cells
Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK
Malaria Blood Stage Suppression of Liver Stage Immunity by Dendritic Cells
Prospective Estimation of Recombination Signal Efficiency and Identification of Functional Cryptic Signals in the Genome by Statistical Modeling
T Cell Accumulation in B Cell Follicles Is Regulated by Dendritic Cells and Is Independent of B Cell Activation
Unique Resistance of I/LnJ Mice to a Retrovirus Is Due to Sustained Interferon –dependent Production of Virus-neutralizing Antibodies
2003年第197卷第3期
A Mouse with a Loss-of-function Mutation in the c-Cbl TKB Domain Shows Perturbed Thymocyte Signaling without Enhancing the Activity of the ZAP-70 Tyrosine Kin
A Role of Suppressor of Cytokine Signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated Interleukin 2 Production
Activation of Dendritic Cells through the Interleukin 1 Receptor 1 Is Critical for the Induction of Autoimmune Myocarditis
Changes in Chromatin Accessibility Across the GM-CSF Promoter upon T Cell Activation Are Dependent on Nuclear Factor B Proteins
Transgenic Expression of the Activating Natural Killer Receptor Ly49H Confers Resistance to Cytomegalovirus in Genetically Susceptible Mice
The Poxvirus Protein A52R Targets Toll-like Receptor Signaling Complexes to Suppress Host Defense
T Cell Regulation as a Side Effect of Homeostasis and Competition
Sustained Activation of Cell Adhesion Is a Differentially Regulated Process in B Lymphopoiesis
Selective Activation of the c-Jun NH2-terminal Protein Kinase Signaling Pathway by Stimulatory KIR in the Absence of KARAP/DAP12 in CD4+ T Cells
Second Class MinorsMolecular Identification of the Autosomal H46 Histocompatibility Locus as a Peptide Presented by Major Histocompatibility Complex Class II
Restricting Zap70 Expression to CD4+CD8+ Thymocytes Reveals a T Cell Receptor–dependent Proofreading Mechanism Controlling the Completion of Positive Selectio
Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide
Regulation of Lymphocyte Apoptosis by Interferon Regulatory Factor 4 (IRF-4)
Prevention of Arthritis by Interleukin 10–producing B Cells
Interleukin 1 Receptor Dependence of Serum Transferred Arthritis Can be Circumvented by Toll-like Receptor 4 Signaling
Integrin-dependence of Lymphocyte Entry into the Splenic White Pulp
In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8+ T Cells
Immunotherapy of Cytotoxic T Cell–resistant Tumors by T Helper 2 CellsAn Eotaxin and STAT6-dependent Process
2005年第201卷第1期
Role of 2-integrins for homing and neovascularization capacity of endothelial progenitor cells
Do developing B cells need antigen
Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness
Identification and characterization of an endogenous chemotactic ligand specific for FPRL2
Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines
Hypoxia-induced neutrophil survival is mediated by HIF-1–dependent NF-B activity
Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
Conversion of CD4+ CD25– cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II–restricted T cells in the absence of CD4
Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion
TACI and BAFF-R mediate isotype switching in B cells
Positive selection of the peripheral B cell repertoire in gut-associated lymphoid tissues
NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor 1 production
Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
2005年第201卷第2期
NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145
IL-12– and IL-23–induced T helper cell subsets : birds of the same feather flock together
Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
High frequency of antitumor T cells in the blood of melanoma patients before and after vaccination with tumor antigens
Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen
The Pim kinases control rapamycin-resistant T cell survival and activation
Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
Cotranslational endoplasmic reticulum assembly of FcRI controls the formation of functional IgE-binding receptors
Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit
Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues
Broadening the horizons for yellow fever : new uses for an old vaccine
Prevention of UV radiation–induced immunosuppression by IL-12 is dependent on DNA repair
NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells
Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells
BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma
Yellow fever 17D as a vaccine vector for microbial CTL epitopes : protection in a rodent malaria model
2005年第201卷第3期
Regulation of T helper type 2 cell differentiation by murine Schnurri-2
Bacterial toxins and the immune system : show me the in vivo targets
LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration
Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells
MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture
Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45
Synergistic role of micronemal proteins in Toxoplasma gondii virulence
Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner
RAGE limits regeneration after massive liver injury by coordinated suppression of TNF- and NF-B
Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling
Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling
Direct in vivo VH to JH rearrangement violating the 12/23 rule
CD8+ immunodominance among Epstein-Barr virus lytic cycle antigens directly reflects the efficiency of antigen presentation in lytically infected cells
The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation
Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment
Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo
2005年第201卷第4期
Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule
Twisting tails exposed : the evidence for TCR conformational change
Early appearance of germinal center–derived memory B cells and plasma cells in blood after primary immunization
The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo
An orderly inactivation of intracellular retention signals controls surface expression of the T cell antigen receptor
Lineage relationships, homeostasis, and recall capacities of central– and effector–memory CD8 T cells in vivo
Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy
The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival
Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses
Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization
MSH2–MSH6 stimulates DNA polymerase , suggesting a role for A:T mutations in antibody genes
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
Identifying protein–protein interactions in somatic hypermutation
Selecting B cells and plasma cells to memory
Movies, measurement, and modeling : the three Ms of mechanistic immunology
On imaging, speed, and the future of lymphocyte signaling
Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin
T cell receptor engagement by peptide–MHC ligands induces a conformational change in the CD3 complex of thymocytes
Private specificities of CD8 T cell responses control patterns of heterologous immunity
2005年第201卷第5期
Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
Private aspects of heterologous immunity
Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
T cells that cannot respond to TGF- escape control by CD4+CD25+ regulatory T cells
A role for IgG immune complexes during infection with the intracellular pathogen Leishmania
Mycobacterial catalase–peroxidase is a tissue antigen and target of the adaptive immune response in systemic sarcoidosis
Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period
Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors
Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor–induced Nur77 expression and apoptosis
Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients
An immunoglobulin C-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system
Controlling inflammation : a fat chance
Heterologous T cell immunity in severe hepatitis C virus infection
Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells
Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis
Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product
Defective B cell tolerance checkpoints in systemic lupus erythematosus
2005年第201卷第6期
Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA
Signaling for NKT cell development : the SAP–FynT connection
CD44 is a determinant of inflammatory bone loss
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon- induction
Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
A role for fungal -glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice
A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia–like syndrome in BXH-2 mice
The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein–induced bone formation
Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors
In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma
Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
T cell aging : naive but not young
Identifying genes that regulate bone remodeling as potential therapeutic targets
Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen
Granulocyte/macrophage colony-stimulating factor and accessory cells modulate radioprotection by purified hematopoietic cells
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I
Platelet activation leads to activation and propagation of the complement system
2005年第201卷第7期
Understanding how combinations of HLA and KIR genes influence disease
Repeated stimulation of CD4 effector T cells can limit their protective function
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation
Mutation of the phospholipase C-1–binding site of LAT affects both positive and negative thymocyte selection
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules
Type I interferon dependence of plasmacytoid dendritic cell activation and migration
IL-1 receptor–associated kinase M is a central regulator of osteoclast differentiation and activation
Protection from cytomegalovirus after transplantation is correlated with immediate early 1–specific CD8 T cells
Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor
A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations
Interferon- acts directly on CD8+ T cells to increase their abundance during virus infection
TGF-1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization
Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci
2005年第201卷第8期
CD44 is a physiological E-selectin ligand on neutrophils
Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN
An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells
Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues
Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
Single cell analysis shows decreasing FoxP3 and TGF1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes
IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF
Contribution of DNA polymerase to immunoglobulin gene hypermutation in the mouse
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-
Protection from angiotensin II–mediated vasculotoxic and hypertensive response in mice lacking PI3K
Among B cell non-Hodgkin‘s lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity
Structural and kinetic basis for heightened immunogenicity of T cell vaccines
Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers
T cell–induced hyaluronan production by epithelial cells regulates inflammation
2005年第201卷第9期
Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection
Blocking IL-1 in systemic inflammation
The 3‘ end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four genes
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
Sustained expansion of NKT cells and antigen-specific T cells after injection of -galactosyl-ceramide loaded mature dendritic cells in cancer patients
Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse
Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells
T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer
Identification of proteoglycans as the APRIL-specific binding partners
Antigenic conservation and immunogenicity of the HIV coreceptor binding site
1 Howard Hughes Medical Institute, University of Alabama at Birmingham, Birmingham, AL 35294
A type I interferon autocrine–paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells
2005年第201卷第10期
Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis
Decay-accelerating factor modulates induction of T cell immunity
Available carbon source influences the resistance of Neisseria meningitidis against complement
TGF-–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease
Impaired early B cell tolerance in patients with rheumatoid arthritis
Induction of vascular leakage through release of bradykinin and a novel kinin by cysteine proteinases from Staphylococcus aureus
IB kinase (IKK), but not IKK, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance
In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses
A cytomegaloviral protein reveals a dual role for STAT2 in IFN- signaling and antiviral responses
Antigen persistence is required throughout the expansion phase of a CD4+ T cell response
Recruitment of latent pools of high-avidity CD8+ T cells to the antitumor immune response
Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression
Shared reactivity of V2neg T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells
Hematopoietic cells maintain hematopoietic fates upon entering the brain
2005年第201卷第11期
Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis
Mycobacterium tuberculosis and the host response
Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size
Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia
Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion
In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance
Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells
Mimicry of a constitutively active pre–B cell receptor in acute lymphoblastic leukemia cells
SURFIN is a polymorphic antigen expressed on Plasmodium falciparum merozoites and infected erythrocytes
The career of Maclyn McCarty
Mutational escape from CD8+ T cell immunity : HCV evolution, from chimpanzees to man
New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling
Immune evasion versus recovery after acute hepatitis C virus infection from a shared source
An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R
Cellular immune selection with hepatitis C virus persistence in humans
Divergent and convergent evolution after a common-source outbreak of hepatitis C virus
2005年第201卷第12期
No audible wheezing : nuggets and conundrums from mouse asthma models
Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis
IFN- production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors
Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
Importance of integrin LFA-1 deactivation for the generation of immune responses
Repertoire, diversity, and differentiation of specific CD8 T cells are associated with immune protection against human cytomegalovirus disease
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil
Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells
Nonhuman primate models of asthma
Antiviral T cell responses : phalanx or multipronged attack
Shifts in targeting of class switch recombination sites in mice that lack μ switch region tandem repeats or Msh2
Identification of eosinophil lineage–committed progenitors in the murine bone marrow
Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells
Properties and protective value of the secondary versus primary T helper type 1 response to airborne Mycobacterium tuberculosis infection in mice
A chromosomally integrated bacteriophage in invasive meningococci
2005年第202卷第1期
BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation
Dendritic cells star in Vancouver
The timing of TCR expression critically influences T cell development and selection
Differential contributions of central and effector memory T cells to recall responses
Plasmacytoid predendritic cells initiate psoriasis through interferon- production
Inhibition of astroglial nuclear factor B reduces inflammation and improves functional recovery after spinal cord injury
Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27Kip1 degradation
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis
Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
Many roads, one destination for T cell progenitors
Contrasting models of promiscuous gene expression by thymic epithelium
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision
v3-dependent cross-presentation of matrix metalloproteinase–2 by melanoma cells gives rise to a new tumor antigen
Restricted MHC–peptide repertoire predisposes to autoimmunity
Loss of C/EBP cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage
2005年第202卷第2期
Aberrant T cell differentiation in the absence of Dicer
Inborn errors of immunity to infection : the rule rather than the exception
Defective thrombus formation in mice lacking coagulation factor XII
Reciprocal regulation of airway rejection by the inducible gas-forming enzymes heme oxygenase and nitric oxide synthase
Human CD1-restricted T cell recognition of lipids from pollens
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
CD4–CD8– T cells control intracellular bacterial infections both in vitro and in vivo
Dendritic cell maturation by innate lymphocytes : coordinated stimulation of innate and adaptive immunity
Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity
The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells
A malarial cysteine protease is necessary for Plasmodium sporozoite egress from oocysts
A critical role for the programmed death ligand 1 in fetomaternal tolerance
Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes
Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis
2005年第202卷第3期
Macrophage fusion : the making of osteoclasts and giant cells
An essential role for c-FLIP in the efficient development of mature T lymphocytes
Cellular FLICE-inhibitory protein is required for T cell survival and cycling
Multiple organ infection and the pathogenesis of SARS
Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs
Tim-2 regulates T helper type 2 responses and autoimmunity
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils
Balancing diversity and tolerance : lessons from patients with systemic lupus erythematosus
DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells
DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis
CD28 costimulatory signal induces protein arginine methylation in T cells
Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA–peptide tetramers
Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels
2005年第202卷第4期
Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells
Production of type I interferons : plasmacytoid dendritic cells and beyond
Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin
IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites
Inducible DNA breaks in Ig S regions are dependent on AID and UNG
Regulation of TCR and repertoires by local and long-distance control of variable gene segment chromatin structure
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
Possible role of human herpesvirus 8 in the lymphoproliferative disorders in common variable immunodeficiency
Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response
Characterization of the early stages of thymic NKT cell development
11-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells
2005年第202卷第5期
Defective Fas expression exacerbates neurotoxicity in a model of Parkinson‘s disease
MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells
A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients
Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
Adhesive mechanisms governing interferon-producing cell recruitment into lymph nodes
Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor–induced apoptosis
Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation
Osteoclast differentiation independent of the TRANCE–RANK–TRAF6 axis
IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell–dependent type 2 innate immunity
A novel glyco-conjugate vaccine against fungal pathogens
NKG2D function protects the host from tumor initiation
MCP-1 overexpressed in tuberous sclerosis lesions acts as a paracrine factor for tumor development
Repression of SPI2 transcription by nitric oxide-producing, IFN-activated macrophages promotes maturation of Salmonella phagosomes
Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
2005年第202卷第6期
Modifier loci condition autoimmunity provoked by Aire deficiency
Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder
Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo
A role for TSLP in the development of inflammation in an asthma model
Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor
Eosinophil adhesion under flow conditions activates mechanosensitive signaling pathways in human endothelial cells
AID from bony fish catalyzes class switch recombination
Cytosolic phospholipase A2–deficient mice are resistant to experimental autoimmune encephalomyelitis
Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9–mediated progenitor cell mobilization
The structure of human CD23 and its interactions with IgE and CD21
Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node
Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment
Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells
2005年第202卷第7期
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis
FASL –844C polymorphism is associated with increased activation-induced T cell death and risk of cervical cancer
Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions
Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells
The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis
Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells
Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells
V14 NK T cell–triggered IFN- production by Gr-1+CD11b+ cells mediates early graft loss of syngeneic transplanted islets
Tumor cells convert immature myeloid dendritic cells into TGF-–secreting cells inducing CD4+CD25+ regulatory T cell proliferation
IL-18–induced CD83+CCR7+ NK helper cells
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma
Developmental regulation of Foxp3 expression during ontogeny
2005年第202卷第8期
Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4+ CTL
SOCS-1 regulates IL-15–driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential
Fat meets the cholinergic antiinflammatory pathway
Deletion of DOCK2, a regulator of the actin cytoskeleton in lymphocytes, suppresses cardiac allograft rejection
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor––dependent manner
Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling
Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve
The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis
Notch signaling is an important regulator of type 2 immunity
Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
Essential role for CD103 in the T cell–mediated regulation of experimental colitis
2005年第202卷第9期
Characterization of marginal zone B cell precursors
Lost in translation : barriers to implementing clinical immunotherapeutics for autoimmunity
Interaction of CagA with Crk plays an important role in Helicobacter pylori–induced loss of gastric epithelial cell adhesion
The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
CD4 T cells integrate signals delivered during successive DC encounters in vivo
Differential antitumor immunity mediated by NKT cell subsets in vivo
IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508
Protection from Alzheimer‘s-like disease in the mouse by genetic ablation of inducible nitric oxide synthase
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
Live attenuated yellow fever 17D infects human DCs and allows for presentation of endogenous and recombinant T cell epitopes
A role for dual viral hits in causation of subacute sclerosing panencephalitis
The insulin A-chain epitope recognized by human T cells is posttranslationally modified
Suppression of allergic airway inflammation by helminth-induced regulatory T cells
TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
2005年第202卷第10期
BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway
Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen
Where CD4+CD25+ T reg cells impinge on autoimmune diabetes
Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein
PU.1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch
PKC regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1
Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung
The very 5‘ end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions
Humanized mice : are we there yet
The many roads to cross-presentation
Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity
Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-B activation
Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
Gadd45 and Gadd45 are critical for regulating autoimmunity
Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses
2005年第202卷第11期
A fundamental bimodal role for neuropeptide Y1 receptor in the immune system
Regulatory T cells and IL-10 in allergic inflammation
Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent
CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function
Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
Autoantibodies make a U-turn : the toll hypothesis for autoantibody specificity
Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow
Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection
Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development
HIF-1–dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia
Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells
Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity
2005年第202卷第12期
Suppression of tumor formation in lymph nodes by L-selectin–mediated natural killer cell recruitment
Tuberculosis in children and adults : two distinct genetic diseases
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1–dependent pathway
TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
Functionally distinct NKT cell subsets and subtypes
A nonclassical non-V14J18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance
Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b–/–Pdcd1–/– mice
A functional promoter polymorphism in monocyte chemoattractant protein–1 is associated with increased susceptibility to pulmonary tuberculosis
Secretory leucoprotease inhibitor binds to NF-B binding sites in monocytes and inhibits p65 binding
E47 is required for V(D)J recombinase activity in common lymphoid progenitors
2006年第203卷第1期
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-B suppression
Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning
G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis
Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation
LAT-mediated signaling in CD4+CD25+ regulatory T cell development
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock
Identification of the target self-antigens in reperfusion injury
Functional disruption of 4 integrin mobilizes bone marrow–derived endothelial progenitors and augments ischemic neovascularization
Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection
Uptake of Leishmania major by dendritic cells is mediated by Fc receptors and facilitates acquisition of protective immunity
Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
Role of mitochondrial glucocorticoid receptor in glucocorticoid-induced apoptosis
Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo
AID-dependent histone acetylation is detected in immunoglobulin S regions
Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon–producing and dendritic cell development
TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque
Innate secretory antibodies protect against natural Salmonella typhimurium infection
The fate of human Langerhans cells in hematopoietic stem cell transplantation
CCR5 deficiency increases risk of symptomatic West Nile virus infection
2006年第203卷第2期
Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma
Cytolytic responses: cadherins put out the fire
Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice
Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis
The Bcl10–Malt1 complex segregates FcRI-mediated nuclear factor B activation and cytokine production from mast cell degranulation
B cell–deficient NOD.H-2h4 mice have CD4+CD25+ T regulatory cells that inhibit the development of spontaneous autoimmune thyroiditis
The immune paradox of sarcoidosis and regulatory T cells
Block of C/EBP function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations
H2-M3–restricted CD8+ T cells are not required for MHC class Ib–restricted immunity against Listeria monocytogenes
A checkpoint for autoreactivity in human IgM+ memory B cell development
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity
Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin
All is not Toll: new pathways in DNA recognition
T-independent type II immune responses generate memory B cells
Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis
Complete differentiation of CD8+ T cells activated locally within the transplanted liver
Impaired response to Listeria in H2-M3–deficient mice reveals a nonredundant role of MHC class Ib–specific T cells in host defense
Regulation of peripheral T cell activation by calreticulin
Thymic stromal lymphopoietin: master switch for allergic inflammation
Human antibodies induce arthritis in mice deficient in the low-affinity inhibitory IgG receptor FcRIIB
2006年第203卷第3期
In vivo sites and cellular mechanisms of T reg cell–mediated suppression
The primary defect in experimental ileitis originates from a nonhematopoietic source
TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE
Cortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia
IL-7 promotes T cell proliferation through destabilization of p27Kip1
Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery
Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses
Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function
Intensified and protective CD4+ T cell immunity in mice with anti–dendritic cell HIV gag fusion antibody vaccine
In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules
A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition
The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04
Are hemostasis and thrombosis two sides of the same coin
Structure and binding kinetics of three different human CD1d–-galactosylceramide–specific T cell receptors
A polymorphism in the EAAT2 promoter is associated with higher glutamate concentrations and higher frequency of progressing stroke
Orphan nuclear receptor TR3/Nur77 regulates VEGF-A–induced angiogenesis through its transcriptional activity
Loss of the proapoptotic protein, Bim, breaks B cell anergy
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription
Systemic antithrombotic effects of ADAMTS13
Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens
2006年第203卷第4期
Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity
Virus-specific CD4+ T cells: ready for direct attack
Regulation of phosphatidylinositol 3–kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury
Endogenous factors enhance HIV infection of tissue naive CD4 T cells by stimulating high molecular mass APOBEC3G complex formation
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
Tissue expression of PD-L1 mediates peripheral T cell tolerance
CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40
Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis
Secondary memory CD8+ T cells are more protective but slower to acquire a central–memory phenotype
Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
Impaired Langerhans cell migration in psoriasis
Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!
Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide
Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells
Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus
Control of Epstein-Barr virus infection in vitro by T helper cells specific for virion glycoproteins
Evidence for discrete stages of human natural killer cell differentiation in vivo
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells
2006年第203卷第5期
Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene
Platelets secrete stromal cell–derived factor 1 and recruit bone marrow–derived progenitor cells to arterial thrombi in vivo
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi‘s sarcoma
Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates
Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
RAR is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation
The c-FLIP–NH2 terminus (p22-FLIP) induces NF-B activation
The impact of DM on MHC class II–restricted antigen presentation can be altered by manipulation of MHC–peptide kinetic stability
Reprogramming of CTLs into natural killer–like cells in celiac disease
A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis
Protective immune responses against West Nile virus are primed by distinct complement activation pathways
Maintenance of viral suppression in HIV-1–infected HLA-B57+ elite suppressors despite CTL escape mutations
Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus
Cholesterol deficiency in a mouse model of Smith-Lemli-Opitz syndrome reveals increased mast cell responsiveness
Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma
A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia
Mechanisms imposing the V bias of V14 natural killer T cells and consequences for microbial glycolipid recognition
Bax does not have to adopt its final form to drive T cell death
NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis
2006年第203卷第6期
IFN-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice
Plasmacytoid dendritic cell–specific receptor ILT7–FcRI inhibits Toll-like receptor–induced interferon production
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
Dysregulated T cell expression of TIM3 in multiple sclerosis
Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1
Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells
Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system
Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality
Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7–dependent homeostatic proliferation of CD4+ T cells
Impaired degranulation but enhanced cytokine production after FcRI stimulation of diacylglycerol kinase –deficient mast cells
A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression
T helper type 1–specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN- promoter are Stat4 dependent
An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands
Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils
Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge
The E enhancer controls the generation of CD4–CD8– TCR-expressing T cells that can give rise to different lineages of T cells
SAP regulates T cell–mediated help for humoral immunity by a mechanism distinct from cytokine regulation
Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production
Differential synergy of Notch and T cell receptor signaling determines versus lineage fate
Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine
2006年第203卷第7期
Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4+ T cells after FcRII-mediated uptake
Role of HMGB1 in apoptosis-mediated sepsis lethality
Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
The clone size of peripheral CD8 T cells is regulated by TCR promiscuity
The BRAF–MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes
ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability
An autosomal dominant major gene confers predisposition to pulmonary tuberculosis in adults
A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts
Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci
Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4
X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production
Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction
Ig tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization
Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-B in B cell clonal anergy
Essential role of IPS-1 in innate immune responses against RNA viruses
2006年第203卷第8期
Antiviral defense: interferons and beyond
The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60
NK cells promote transplant tolerance by killing donor antigen-presenting cells
Enhancement of clonogenicity of human multiple myeloma by dendritic cells
Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors
Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27
Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1
Regulation of lymph node vascular growth by dendritic cells
Twist mediates suppression of inflammation by type I IFNs and Axl
Neutrophils from p40phox–/– mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing
The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcIIA receptor–induced phagocytosis
Cerebral microcirculation shear stress levels determine Neisseria meningitidis attachment sites along the blood–brain barrier
Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages
Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection
Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands
Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17
An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues
Nonneutralizing antibodies binding to the surface glycoprotein of lymphocytic choriomeningitis virus reduce early virus spread
2006年第203卷第9期
Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis
The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine
Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages
Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis
The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2–/– ung–/– mice
In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain
Carbon monoxide reverses established pulmonary hypertension
A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant
Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response
Elimination of chronic viral infection by blocking CD27 signaling
Selective dysregulation of the FcIIB receptor on memory B cells in SLE
Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction
The plasminogen activator system modulates sympathetic nerve function
NF-B translocation prevents host cell death after low-dose challenge by Legionella pneumophila
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
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The BRAF–MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells
Mycobacterium tuberculosis and the host response
Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
Cerebral microcirculation shear stress levels determine Neisseria meningitidis attachment sites along the blood–brain barrier
Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
T-independent type II immune responses generate memory B cells
DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells
A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations
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