- Nuclear Localization of NADPH:Cytochrome c (P450) Reductase Enhances the Cytotoxicity of Mitomycin C to Chinese Hamster Ovary Cells
- The mGluR5 Antagonist 6-Methyl-2-(phenylethynyl)pyridine Decreases Ethanol Consumption via a Protein Kinase C-Dependent Mechanism
- Proteasomal Degradation of Human CYP1B1: Effect of the Asn453Ser Polymorphism on the Post-Translational Regulation of CYP1B1 Expression
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Insulin-Like Growth Factor Binding Protein-1 Gene Expression and Counteracts the Negative Effect of Insulin
- Characterization of Binding of Folates and Antifolates to Brush-Border Membrane Vesicles Isolated from Human Kidney
- Evidence for Negative Binding Cooperativity within CCR5-CCR2b Heterodimers
- Picrotoxin Accelerates Relaxation of GABAC Receptors
- Kv2.1 Channel Activation and Inactivation Is Influenced by Physical Interactions of Both Syntaxin 1A and the Syntaxin 1A/Soluble N-Ethylmaleimide-Sensitive Fa
- Steroidogenic Factor-1 Interacts with cAMP Response Element-Binding Protein to Mediate cAMP Stimulation of CYP1B1 via a Far Upstream Enhancer
- Identification of Amino Acid Residues in the Insect Sodium Channel Critical for Pyrethroid Binding
- Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison
- Cyclooxygenase Inhibitors Induce the Expression of the Tumor Suppressor Gene EGR-1, Which Results in the Up-Regulation of NAG-1, an Antitumorigenic Protein
- Membrane Structure Modulation, Protein Kinase C Activation, and Anticancer Activity of Minerval
- Inhibition of L-Type Cav1.2 Ca2+ Channels by 2,(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-Dimethyl-aminopropyl)-5-methoxyindol-3-yl
- Transport of Bile Acids, Sulfated Steroids, Estradiol 17--D-Glucuronide, and Leukotriene C4 by Human Multidrug Resistance Protein 8 (ABCC11)
- Negative Regulation of TRPC3 Channels by Protein Kinase C-Mediated Phosphorylation of Serine 712
- Isoform-Specific Regulation of Adenylyl Cyclase Function by Disruption of Membrane Trafficking
- N3-Methyladenine Induces Early Poly(ADP-Ribosylation), Reduction of Nuclear Factor-B DNA Binding Ability, and Nuclear Up-Regulation of Telomerase Activity
- A Multifunctional Aromatic Residue in the External Pore Vestibule of Na+ Channels Contributes to the Local Anesthetic Receptor
- P-Glycoprotein Substrate Binding Domains Are Located at the Transmembrane Domain/Transmembrane Domain Interfaces: A Combined Photoaffinity Labeling-Protein Ho
- Effects of Valproic Acid Derivatives on Inositol Trisphosphate Depletion, Teratogenicity, Glycogen Synthase Kinase-3 Inhibition, and Viral Replication: A Scre
- Adenosine in Tissue Protection and Tissue Regeneration
- Palmitoylation of the 5-Hydroxytryptamine4a Receptor Regulates Receptor Phosphorylation, Desensitization, and -Arrestin-Mediated Endocytosis
- Blockade of Vascular Endothelial Growth Factor Receptor Signal Pathway and Antitumor Activity of ON-III (2‘,4‘-Dihydroxy-6‘-methoxy-3‘,5‘-dimethylchalcone), a
- Vacuolar Degradation of Rat Liver CYP2B1 in Saccharomyces cerevisiae: Further Validation of the Yeast Model and Structural Implications for the Degradation of
- Antiangiogenic and Vascular-Targeting Activity of the Microtubule-Destabilizing trans-Resveratrol Derivative 3,5,4‘-Trimethoxystilbene
- Structural Features of the Glutamate Binding Site in Recombinant NR1/NR2A N-Methyl-D-aspartate Receptors Determined by Site-Directed Mutagenesis and Molecular
- Modulation of Cellular Response to Cisplatin by a Novel Inhibitor of DNA Polymerase
- -Adrenergic Receptor Stimulation Promotes Gs Internalization through Lipid Rafts: A Study in Living Cells
- Investigations of Calsequestrin as a Target for Anthracyclines: Comparison of Functional Effects of Daunorubicin, Daunorubicinol, and Trifluoperazine
- Stichodactyla helianthus Peptide, a Pharmacological Tool for Studying Kv3.2 Channels
- Isoflurane Induces a Protein Kinase C -Dependent Increase in Cell-Surface Protein Level and Activity of Glutamate Transporter Type 3
- From Plants to Man: The GPCR “Tree of Life“
- Heparan Sulfate Regulates the Antiangiogenic Activity of Endothelial Monocyte-Activating Polypeptide-II at Acidic pH
- A Synthetic Derivative of the Natural Product Rocaglaol Is a Potent Inhibitor of Cytokine-Mediated Signaling and Shows Neuroprotective Activity in Vitro and i
- Marked Depletion of Glycosylation Sites in HIV-1 gp120 under Selection Pressure by the Mannose-Specific Plant Lectins of Hippeastrum Hybrid and Galanthus niva
- Superagonistic Action of 14-epi-Analogs of 1,25-Dihydroxyvitamin D Explained by Vitamin D Receptor-Coactivator Interaction
- A Novel and Efficient Approach to Discriminate between Pre- and Post-Transcription HIV Inhibitors
- Subtype-Specific Sorting of the ETA Endothelin Receptor by a Novel Endocytic Recycling Signal for G Protein-Coupled Receptors
- The General Anesthetic Isoflurane Depresses Synaptic Vesicle Exocytosis
- The Neurotransmitter Noradrenaline Rescues Septal Cholinergic Neurons in Culture from Degeneration Caused by Low-Level Oxidative Stress
- What‘s for Lunch at the Conformational Cafeteria
- Differential Spatial Approximation between Cholecystokinin Residue 30 and Receptor Residues in Active and Inactive Conformations
- Taipoxin Induces Synaptic Vesicle Exocytosis and Disrupts the Interaction of Synaptophysin I with VAMP2
- Endoplasmic Reticulum Stress Links Dyslipidemia to Inhibition of Proteasome Activity and Glucose Transport by HIV Protease Inhibitors
- Identification and Characterization of PDE4A11, a Novel, Widely Expressed Long Isoform Encoded by the Human PDE4A cAMP Phosphodiesterase Gene
- Retinoids Potentiate Peroxisome Proliferator-Activated Receptor Action in Differentiation, Gene Expression, and Lipid Metabolic Processes in Developing Myelo
- Functional Interactions Between Nucleotide Binding Domains and Leukotriene C4 Binding Sites of Multidrug Resistance Protein 1 (ABCC1)
- Antimalarial Artemisinin Drugs Induce Cytochrome P450 and MDR1 Expression by Activation of Xenosensors Pregnane X Receptor and Constitutive Androstane Recepto
- Mutation of the DRY Motif Reveals Different Structural Requirements for the CC Chemokine Receptor 5-Mediated Signaling and Receptor Endocytosis
- The Effects of Subunit Composition on the Inhibition of Nicotinic Receptors by the Amphipathic Blocker 2,2,6,6-Tetramethylpiperidin-4-yl Heptanoate
- Farnesyltransferase Inhibitor BMS-214662 Induces Apoptosis in Myeloma Cells through PUMA Up-Regulation, Bax and Bak Activation, and Mcl-1 Elimination
- Centaurin-1, an ADP-Ribosylation Factor 6 GTPase Activating Protein, Inhibits 2-Adrenoceptor Internalization
- Breast Cancer Resistance Protein (Bcrp1/Abcg2) Limits Net Intestinal Uptake of Quercetin in Rats by Facilitating Apical Efflux of Glucuronides
- Expression of Nigrostriatal 6-Containing Nicotinic Acetylcholine Receptors Is Selectively Reduced, but Not Eliminated, by 3 Subunit Gene Deletion
- Chemically Distinct Ligands Promote Differential CB1 Cannabinoid Receptor-Gi Protein Interactions
- Neurotensin Stimulates Interleukin-8 Expression through Modulation of IB Phosphorylation and p65 Transcriptional Activity: Involvement of Protein Kinase C
- DNA Methylation-Related Chromatin Modification in the Regulation of Mouse -Opioid Receptor Gene
- Expression of Native 34 Neuronal Nicotinic Receptors: Binding and Functional Studies Investigating Turnover of Surface and Intracellular Receptor Populations
- Cell Cycle Signaling by Endothelin-1 Requires Src Nonreceptor Protein Tyrosine Kinase
- Sulfotransferase (SULT) 1A1 Polymorphic Variants *1, *2, and *3 Are Associated with Altered Enzymatic Activity, Cellular Phenotype, and Protein Degradation
- The Aryl Hydrocarbon Receptor Agonist 2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters the Circadian Rhythms, Quiescence, and Expression of Clock Genes in Murine He
- G12/13- and Rho-Dependent Activation of Phospholipase C- by Lysophosphatidic Acid and Thrombin Receptors
- The Suramin Analog 4,4‘,4‘‘,4‘‘‘-(Carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic Acid (NF110) Potently Blocks P2X3 Recepto
- Ultrasound Stimulates Cyclooxygenase-2 Expression and Increases Bone Formation through Integrin, Focal Adhesion Kinase, Phosphatidylinositol 3-Kinase, and Akt
- Modulation by LL-37 of the Responses of Salivary Glands to Purinergic Agonists
- In Vitro and in Vivo Nuclear Factor-B Inhibitory Effects of the Cell-Penetrating Penetratin Peptide
- Dual Potentiating and Inhibitory Actions of a Benz[e]indene Neurosteroid Analog on Recombinant 122 GABAA Receptors
- Recombinant Enzymes Overexpressed in Bacteria Show Broad Catalytic Specificity of Human Cytochrome P450 2W1 and Limited Activity of Human Cytochrome P450 2S1
- Neurochemical Characterization of a Neuroprotective Compound from Parawixia bistriata Spider Venom That Inhibits Synaptosomal Uptake of GABA and Glycine
- The Interaction of an Impermeant Cation with the Sheep Cardiac RyR Channel Alters Ryanoid Association
- Distinct Receptor Activity-Modifying Protein Domains Differentially Modulate Interaction with Calcitonin Receptors
- Potentiation of Native and Recombinant P2X7-Mediated Calcium Signaling by Arachidonic Acid in Cultured Cortical Astrocytes and Human Embryonic Kidney 293 Cell
- Desensitization of NO/cGMP Signaling in Smooth Muscle: Blood Vessels Versus Airways
- T-Type Calcium Channels Are Inhibited by Fluoxetine and Its Metabolite Norfluoxetine
- A Constitutively Active Hypoxia-Inducible Factor-1/VP16 Hybrid Factor Activates Expression of the Human B-Type Natriuretic Peptide Gene
- 2-Fluoro-3-(4-nitro-phenyl)deschloroepibatidine Is a Novel Potent Competitive Antagonist of Human Neuronal 42 nAChRs
- Suppression of the Phosphorylation of Receptor Tyrosine Phosphatase- on the Src-Independent Site Tyrosine 789 by Reactive Oxygen Species
- Phoneutria nigriventer Toxin 1: A Novel, State-Dependent Inhibitor of Neuronal Sodium Channels That Interacts with μ Conotoxin Binding Sites
- A Common Regulatory Region Functions Bidirectionally in Transcriptional Activation of the Human CYP1A1 and CYP1A2 Genes
- The Regulator of G Protein Signaling Domain of Axin Selectively Interacts with G12 but Not G13
- Sazetidine-A, A Novel Ligand That Desensitizes 4β2 Nicotinic Acetylcholine Receptors without Activating Them
- Ras-Dependent Recruitment of c-Myc for Transcriptional Activation of Nucleophosmin/B23 in Highly Malignant U1 Bladder Cancer Cells
- S-Nitrosylating Agents: A Novel Class of Compounds That Increase Cystic Fibrosis Transmembrane Conductance Regulator Expression and Maturation in Epithelial C
- Inhibition of Ca2+ Influx Is Required for Mitochondrial Reactive Oxygen Species-Induced Endoplasmic Reticulum Ca2+ Depletion and Cell Death in Leukemia Cells
- 17β-Estradiol, Genistein, and 4-Hydroxytamoxifen Induce the Proliferation of Thyroid Cancer Cells through the G Protein-Coupled Receptor GPR30
- Point Mutations in Either Subunit of the GABAB Receptor Confer Constitutive Activity to the Heterodimer
- JX401, A p38 Inhibitor Containing a 4-Benzylpiperidine Motif, Identified via a Novel Screening System in Yeast
- Contribution of the Major Copper Influx Transporter CTR1 to the Cellular Accumulation of Cisplatin, Carboplatin, and Oxaliplatin
- Prevention of Platelet Glycoprotein IIb/IIIa Activation by 3,4-Methylenedioxy-β-Nitrostyrene, A Novel Tyrosine Kinase Inhibitor
- Role of Endogenous XAP2 Protein on the Localization and Nucleocytoplasmic Shuttling of the Endogenous Mouse Ahb-1 Receptor in the Presence and Absence of Liga
- β3 Subunits Promote Expression and Nicotine-Induced Up-Regulation of Human Nicotinic 6* Nicotinic Acetylcholine Receptors Expressed in Transfected Cell Lines
- Incorporation of the β3 Subunit Has a Dominant-Negative Effect on the Function of Recombinant Central-Type Neuronal Nicotinic Receptors
- Liver X Receptor (LXR)-β Regulation in LXR-Deficient Mice: Implications for Therapeutic Targeting
- Focal Adhesion Kinase and Protein Kinase B Cooperate to Suppress Doxorubicin-Induced Apoptosis of Breast Tumor Cells
- Biophysical Characterization of the New Human Ether-A-Go-Go-Related Gene Channel Opener NS3623 [N-(4-Bromo-2-(1H-tetrazol-5-yl)-phenyl)-N‘-(3‘-trifluoromethyl
- Molecular Determinants of Pyrantel Selectivity in Nicotinic Receptors
- The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Human Breast Cancer Cell Proliferation through a Lipid Raft-Mediated Mechanism
- Endocrine Regulation of Gender-Divergent Mouse Organic Anion-Transporting Polypeptide (Oatp) Expression
- Regulation of Mouse Hepatic -Amino-β-Carboxymuconate--Semialdehyde Decarboxylase, a Key Enzyme in the Tryptophan-Nicotinamide Adenine Dinucleotide Pathway, by